Evidence map›Paper›PMID 34003344›Full record

ArticleArchives of toxicology2021

Subcellular spatio-temporal intravital kinetics of aflatoxin B

Ahmed Ghallab, Reham Hassan, Maiju Myllys, Wiebke Albrecht, Adrian Friebel, Stefan Hoehme, Ute Hofmann, Abdel-Latif Seddek, Albert Braeuning, Lars Kuepfer and 5 more

Open access · hybridAbstract read
In one paragraph

Article in Archives of toxicology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
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  8. Comparative metabolism of aflatoxin BArchives of toxicology · 2023
    Article
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  12. First Record ofJournal of fungi (Basel, Switzerland) · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 2 countries.

Ahmed GhallabLeibniz Research Centre for Working Environment and Human Factors, Technical University Dortmund, Ardeystr. 67, 44139, Dortmund, Germany. ghallab@ifado.de.ORCID http://orcid.org/0000-0003-0695-3403
Reham HassanLeibniz Research Centre for Working Environment and Human Factors, Technical University Dortmund, Ardeystr. 67, 44139, Dortmund, Germany.
Maiju MyllysLeibniz Research Centre for Working Environment and Human Factors, Technical University Dortmund, Ardeystr. 67, 44139, Dortmund, Germany.
Wiebke AlbrechtLeibniz Research Centre for Working Environment and Human Factors, Technical University Dortmund, Ardeystr. 67, 44139, Dortmund, Germany.
Adrian FriebelInstitute of Computer Science, Saxonian Incubator for Clinical Research (SIKT), University of Leipzig, Haertelstraße 16-18, 04107, Leipzig, Germany.
Stefan HoehmeInstitute of Computer Science, Saxonian Incubator for Clinical Research (SIKT), University of Leipzig, Haertelstraße 16-18, 04107, Leipzig, Germany.
Ute HofmannDr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Auerbachstr. 112, 70376, Stuttgart, Germany.
Abdel-Latif SeddekDepartment of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, South Valley University, Qena, 83523, Egypt.
Albert BraeuningDepartment of Food Safety, German Federal Institute for Risk Assessment, Max-Dohrn-Str. 8-10, 10589, Berlin, Germany.
Lars KuepferInstitute of Systems Medicine with Focus on Organ Interactions, University Hospital RWTH Aachen, Pauwelsstr. 19, 52074, Aachen, Germany.
Benedikt CramerInstitute of Food Chemistry, Westfälische Wilhelms-Universität Münster, Corrensstr. 45, 48149, Münster, Germany.
Hans-Ulrich HumpfInstitute of Food Chemistry, Westfälische Wilhelms-Universität Münster, Corrensstr. 45, 48149, Münster, Germany.
Peter BoorInstitute of Pathology and Department of Nephrology, University Hospital RWTH Aachen, Pauwelsstr. 30, 52074, Aachen, Germany.
Gisela H Degen *Leibniz Research Centre for Working Environment and Human Factors, Technical University Dortmund, Ardeystr. 67, 44139, Dortmund, Germany. degen@ifado.de.
Jan G Hengstler *Leibniz Research Centre for Working Environment and Human Factors, Technical University Dortmund, Ardeystr. 67, 44139, Dortmund, Germany. hengstler@ifado.de.
TU Dortmund University · DESouth Valley University · EGRWTH Aachen University · DEUniversity of Münster · DEDr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology · DEFederal Institute for Risk Assessment · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Local accumulation of xenobiotics in human and animal tissues may cause adverse effects. Large differences in their concentrations may exist between individual cell types, often due to the expression of specific uptake and export carriers. Here we established a two-photon microscopy-based technique for spatio-temporal detection of the distribution of mycotoxins in intact kidneys and livers of anesthetized mice with subcellular resolution. The mycotoxins ochratoxin A (OTA, 10 mg/kg b.w.) and aflatoxin B

Indexed as

Aflatoxin B1AnimalsCytochrome P-450 Enzyme SystemHalf-LifeHepatocytesKidneyLiverMaleMiceMice, Inbred C57BLMicroscopyOchratoxinsSpatio-Temporal AnalysisTissue DistributionAflatoxin B1Cytochrome P-450 Enzyme Systemochratoxin AOchratoxinsIn vivo imagingMycotoxinsPharmacokineticsTwo-photon

Identifiers

PMID34003344
PMCPMC8166722
OpenAlexW3162228558

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.