ArticlePlant cell reports2021
Exogenous melatonin regulates endogenous phytohormone homeostasis and thiol-mediated detoxification in two indica rice cultivars under arsenic stress.
Article in Plant cell reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.
- Machine learning-assisted meta-analysis reveals melatonin crosstalk regulating plant growth plasticity under heavy metal stress.Plant cell reports · 2026Pooled it
- Abscisic acid interplay with phytohormones, plant growth regulators and signaling molecules in orchestrating an elaborate crosstalk for stress resilience in plants.Biologia futura · 2026Review
- Transporter promiscuity and redox-driven metal partitioning in plant responses to chemically analogous metals.Plant cell reports · 2026Review
- Molecular insights into melatonin-mediated stress tolerance in rice.Plant cell reports · 2025Review
- Biochar and Melatonin Partnership Mitigates Arsenic Toxicity in Rice by Modulating Antioxidant Defense, Phytochelatin Synthesis, and Down-Regulating the Transporters Involved in Arsenic Uptake.Plants (Basel, Switzerland) · 2025Article
- Melatonin integrates multiple biological and phytohormonal pathways to enhance drought tolerance in rice.Planta · 2025Article
- Melatonin enhances salt tolerance by promoting CcCAD10-mediated lignin biosynthesis in pigeon pea.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- Identification, characterization, and expression of Oryza sativa tryptophan decarboxylase genes associated with fluroxypyr-meptyl metabolism.The plant genome · 2025Article
- Melatonin improves the lead tolerance in Plantago ovata by modulating ROS homeostasis, phytohormone status and expression of stress-responsive genes.Plant cell reports · 2025Article
- ABA and Melatonin: Players on the Same Field?International journal of molecular sciences · 2024Article
- Crosstalk between melatonin and nitric oxide restrains Cadmium-induced oxidative stress and enhances vinblastine biosynthesis in Catharanthus roseus (L) G Don.Plant cell reports · 2024Article
- Melatonin Alleviates Antimony Toxicity by Regulating the Antioxidant Response and Reducing Antimony Accumulation inAntioxidants (Basel, Switzerland) · 2023Article
- Abscisic acid in plants under abiotic stress: crosstalk with major phytohormones.Plant cell reports · 2023Review
- Deciphering the melatonin-mediated response and signalling in the regulation of heavy metal stress in plants.Planta · 2023Review
- Melatonin Alleviates Chromium Toxicity in Maize by Modulation of Cell Wall Polysaccharides Biosynthesis, Glutathione Metabolism, and Antioxidant Capacity.International journal of molecular sciences · 2023Article
- 5-Aminolevulinic Acid Induces Chromium [Cr(VI)] Tolerance in Tomatoes by Alleviating Oxidative Damage and Protecting Photosystem II: A Mechanistic Approach.Plants (Basel, Switzerland) · 2023Article
- Arsenic perception and signaling: The yet unexplored world.Frontiers in plant science · 2022Review
- Melatonin-Mediated Abiotic Stress Tolerance in Plants.Frontiers in plant science · 2022Review
- Effects of Plant Hormones, Metal Ions, Salinity, Sugar, and Chemicals Pollution on Glucosinolate Biosynthesis in Cruciferous Plant.Frontiers in plant science · 2022Review
Corrections and comments
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3 authors at 1 institution in 1 country.
Funding
Abstract
key messageMelatonin enhanced arsenic (As) tolerance by inhibiting As bioaccumulation, modulating the expression of As transporters and phytohormone homeostasis, leading to efficient utilization of thiol machinery for sequestration and detoxification of this toxic metalloid. The present study was aimed at investigating the influence of exogenous melatonin on the regulation of endogenous plant growth regulators and their cumulative effects on metal(loid)-binding ligands in two contrasting indica rice cultivars, viz., Khitish (arsenic sensitive) and Muktashri (arsenic tolerant) under arsenic stress. Melatonin supplementation ameliorated arsenic-induced perturbations by triggering endogenous levels of gibberellic acid and melatonin, via up-regulating the expression of key biosynthetic genes like GA3ox, TDC, SNAT and ASMT. The endogenous abscisic acid content was also enhanced upon melatonin treatment by induced expression of the key anabolic gene, NCED3 and concomitant suppression of ABA8ox1. Enhanced melatonin content induced accumulation of higher polyamines (spermidine and spermine), together with up-regulation of SPDS and SPMS in Khitish, thereby modulating stress condition. On the contrary, melatonin escalated putrescine and spermidine levels in Muktashri, via enhanced expression of ADC and SAMDC. The role of melatonin appeared to be more prominent in Khitish, as evident from better utilization of thiol components like cysteine, GSH, non-protein thiols and phytochelatins, with higher GSH/GSSG ratio, despite down-regulated expression of corresponding thiol-metabolic genes (OsMT2 and OsPCS1) to deal with arsenic toxicity. The extent of arsenic bioaccumulation, which was magnified several folds, particularly in Khitish, was decreased upon melatonin application. Overall, our observation highlighted the fact that melatonin enhanced arsenic tolerance by inhibiting arsenic bioaccumulation, via modulating the expression levels of selected arsenic transporters (OsNramp1, OsPT2, OsPT8, OsLsi1) and controlling endogenous phytohormone homeostasis, leading to efficient utilization of thiol machinery for sequestration and detoxification of this toxic metalloid.
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