[Long covid syndrome and real world evidence.]

Long covid syndrome is increasingly studied and debated. The number of scientific publications is growing and groups and associations of patients affected by the syndrome are increasingly active. There is concern that international attention to this syndrome could lead to an excess of diagnostic procedures and unnecessary medical interventions. On the other hand, we have a robust body of evidence of a constellation of symptoms and ailments suffered by patients recovered from covid-19. Tackling this problem therefore means tackling coexistence with covid-19 in the long term, annexing this pathology in a chronic perspective. The collection and analysis of data, therefore, could already allow a stratification of populations at risk, putting social and services in a position to respond adequately to the demand for assistance that is expected to be received by a very large number of patients. But it is essential that real-world evidence goes hand in hand with the selection, analysis and interpretation of information collected in administrative databases, disease registers and databases developed by universities and institutions to promote public health truly personalized.