Evidence map›Paper›PMID 34003115›Full record

ArticleeLife2021

Competitive coordination of the dual roles of the Hedgehog co-receptor in homophilic adhesion and signal reception.

Shu Yang, Ya Zhang, Chuxuan Yang, Xuefeng Wu, Sarah Maria El Oud, Rongfang Chen, Xudong Cai, Xufeng S Wu, Ganhui Lan, Xiaoyan Zheng

Open access · goldAbstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. From mesenchymal niches to engineeredMaterials today. Bio · 2022
    Article
  6. Article
  7. Regulatory mechanisms of cytoneme-based morphogen transport.Cellular and molecular life sciences : CMLS · 2022
    Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Shu Yang *Department of Anatomy and Cell Biology, George Washington University School of Medicine and Health Sciences, Washington, United States.ORCID 0000-0001-8909-1962
Ya Zhang *Department of Anatomy and Cell Biology, George Washington University School of Medicine and Health Sciences, Washington, United States.ORCID 0000-0001-9060-3777
Chuxuan Yang *Department of Physics, George Washington University, Washington, United States.
Xuefeng WuDepartment of Anatomy and Cell Biology, George Washington University School of Medicine and Health Sciences, Washington, United States.
Sarah Maria El OudDepartment of Physics, George Washington University, Washington, United States.
Rongfang ChenDepartment of Anatomy and Cell Biology, George Washington University School of Medicine and Health Sciences, Washington, United States.
Xudong CaiDepartment of Anatomy and Cell Biology, George Washington University School of Medicine and Health Sciences, Washington, United States.
Xufeng S WuLaboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, United States.
Ganhui LanDepartment of Physics, George Washington University, Washington, United States.ORCID 0000-0003-3768-4111
Xiaoyan ZhengDepartment of Anatomy and Cell Biology, George Washington University School of Medicine and Health Sciences, Washington, United States.ORCID 0000-0003-4983-5503
George Washington University · USNational Institutes of Health · US

Funding

The role of ciliary trafficking in Hedgehog receptor functionR01GM117440 · NIGMS · GEORGE WASHINGTON UNIVERSITY · PI ZHENG, XIAOYAN · 2017 to 2021
$1.7M
NIGMS NIH HHS R01 GM117440
6 · The paper itself

Abstract

Hedgehog (Hh) signaling patterns embryonic tissues and contributes to homeostasis in adults. In

Indexed as

AnimalsCell LineDrosophila melanogasterDrosophila ProteinsHedgehog ProteinsMembrane GlycoproteinsModels, TheoreticalProtein DomainsReceptors, Cell SurfaceSignal TransductionDrosophila ProteinsHedgehog ProteinsiHog protein, DrosophilaMembrane GlycoproteinsReceptors, Cell Surfacecytonemedevelopmental biologyD. melanogasterdual roleHedgehog signalingtrans-homophilic binding

Identifiers

PMID34003115
PMCPMC8131103
OpenAlexW3163821331

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.