Evidence map›Paper›PMID 34003111›Full record

ArticleeLife2021

PIE-1 SUMOylation promotes germline fates and piRNA-dependent silencing in

Heesun Kim, Yue-He Ding, Shan Lu, Mei-Qing Zuo, Wendy Tan, Darryl Conte, Meng-Qiu Dong, Craig C Mello

Open access · goldAbstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Analysis ofComputational and structural biotechnology journal · 2024
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Regulation of SUMOylation on RNA metabolism in cancers.Frontiers in molecular biosciences · 2023
    Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Heesun Kim *RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, United States.ORCID 0000-0001-7643-4516
Yue-He Ding *RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, United States.
Shan LuNational Institute of Biological Sciences, Beijing, China.
Mei-Qing ZuoNational Institute of Biological Sciences, Beijing, China.
Wendy TanRNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, United States.
Darryl ConteRNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, United States.ORCID 0000-0002-1137-8901
Meng-Qiu DongNational Institute of Biological Sciences, Beijing, China.ORCID 0000-0002-6094-1182
Craig C MelloRNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, United States.ORCID 0000-0001-9176-6551
University of Massachusetts Chan Medical School · USNational Institute of Biological Sciences, Beijing · CNHoward Hughes Medical Institute · US

Funding

RNA MEDIATED GENETIC INTERFERENCE IN C ELEGANSR01GM058800 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI MELLO, CRAIG C · 1999 to 2014
$4.6M
RNA Mediated Genetic Interference in C. elegansR37GM058800 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI MELLO, CRAIG C · 2015 to 2024
$3.7M
Howard Hughes Medical InstituteNIGMS NIH HHS R01 GM058800NIGMS NIH HHS R37 GM058800
6 · The paper itself

Abstract

Germlines shape and balance heredity, integrating and regulating information from both parental and foreign sources. Insights into how germlines handle information have come from the study of factors that specify or maintain the germline fate. In early

Indexed as

AnimalsArgonaute ProteinsCaenorhabditis elegansCaenorhabditis elegans ProteinsCell DifferentiationFemaleMeiosisNuclear ProteinsOvumRNA, Small InterferingSumoylationArgonaute ProteinsCaenorhabditis elegans ProteinsNuclear Proteinspie-1 protein, C elegansRNA, Small InterferingC. elegansgeneticsgenomicsgermline chromatingermline fateNuRD complexSUMO pathway

Identifiers

PMID34003111
PMCPMC8131105
OpenAlexW3161870280

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.