Evidence map›Paper›PMID 34003109›Full record

ArticleeLife2021

HDAC1 SUMOylation promotes Argonaute-directed transcriptional silencing in

Heesun Kim, Yue-He Ding, Gangming Zhang, Yong-Hong Yan, Darryl Conte, Meng-Qiu Dong, Craig C Mello

Open access · goldAbstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 33 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Heesun Kim *RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, United States.ORCID 0000-0001-7643-4516
Yue-He Ding *RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, United States.
Gangming ZhangRNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, United States.
Yong-Hong YanNational Institute of Biological Sciences, Beijing, China.
Darryl ConteRNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, United States.ORCID 0000-0002-1137-8901
Meng-Qiu DongNational Institute of Biological Sciences, Beijing, China.ORCID 0000-0002-6094-1182
Craig C MelloRNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, United States.ORCID 0000-0001-9176-6551
University of Massachusetts Chan Medical School · USNational Institute of Biological Sciences, Beijing · CNHoward Hughes Medical Institute · US

Funding

RNA MEDIATED GENETIC INTERFERENCE IN C ELEGANSR01GM058800 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI MELLO, CRAIG C · 1999 to 2014
$4.6M
RNA Mediated Genetic Interference in C. elegansR37GM058800 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI MELLO, CRAIG C · 2015 to 2024
$3.7M
Howard Hughes Medical InstituteNIGMS NIH HHS R01 GM058800NIGMS NIH HHS R37 GM058800
6 · The paper itself

Abstract

Eukaryotic cells use guided search to coordinately control dispersed genetic elements. Argonaute proteins and their small RNA cofactors engage nascent RNAs and chromatin-associated proteins to direct transcriptional silencing. The small ubiquitin-like modifier (SUMO) has been shown to promote the formation and maintenance of silent chromatin (called heterochromatin) in yeast, plants, and animals. Here, we show that Argonaute-directed transcriptional silencing in

Indexed as

SumoylationTranscription, GeneticAnimalsArgonaute ProteinsCaenorhabditis elegansChromatin Assembly and DisassemblyGene SilencingHeterochromatinHistone Deacetylase 1RNA InterferenceRNA, Small InterferingArgonaute ProteinsHeterochromatinHistone Deacetylase 1RNA, Small InterferingC. elegansdevelopmental biologygermlineHDAC SUMOylationnuclear argonaut

Identifiers

PMID34003109
PMCPMC8131101
OpenAlexW3162221439

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.