ArticleeLife2021
The organizational principles of de-differentiated topographic maps in somatosensory cortex.
Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed.
- Cutting a nerve of the hand alters the organization of digit maps in primary somatosensory cortex.Nature human behaviour · 2026Article
- Evaluation of the Manual Dexterity of Second-Year Dental Students after One Semester of Preclinical Training.European journal of dentistry · 2026Article
- Layer-specific changes in sensory cortex across the lifespan in mice and humans.Nature neuroscience · 2025Article
- Tactile memory impairments in younger and older adults.Scientific reports · 2024Article
- Representational maps in the brain: concepts, approaches, and applications.Frontiers in cellular neuroscience · 2024Review
- The 3D Structural Architecture of the Human Hand Area Is Nontopographic.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Discriminating Free Hand Movements Using Support Vector Machine and Recurrent Neural Network Algorithms.Sensors (Basel, Switzerland) · 2022Article
- Relationship between Tactile Sensation, Motor Activity, and Differential Brain Activity in Young Individuals.Brain sciences · 2022Article
- Article
- The organizational principles of de-differentiated topographic maps in somatosensory cortex.eLife · 2021Article
- Modeling 2D spatio-tactile population receptive fields of the fingertip in human primary somatosensory cortex.Imaging neuroscience (Cambridge, Mass.)Article
- Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Topographic maps are a fundamental feature of cortex architecture in the mammalian brain. One common theory is that the de-differentiation of topographic maps links to impairments in everyday behavior due to less precise functional map readouts. Here, we tested this theory by characterizing de-differentiated topographic maps in primary somatosensory cortex (SI) of younger and older adults by means of ultra-high resolution functional magnetic resonance imaging together with perceptual finger individuation and hand motor performance. Older adults' SI maps showed similar amplitude and size to younger adults' maps, but presented with less representational similarity between distant fingers. Larger population receptive field sizes in older adults' maps did not correlate with behavior, whereas reduced cortical distances between D2 and D3 related to worse finger individuation but better motor performance. Our data uncover the drawbacks of a simple de-differentiation model of topographic map function, and motivate the introduction of feature-based models of cortical reorganization.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.