ArticleeLife2021
Novel cell types and developmental lineages revealed by single-cell RNA-seq analysis of the mouse crista ampullaris.
Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 48 citations in OpenAlex.
- Multi-omics analysis of ion channels expressed by chicken embryo vestibular type I and type II hair cells.Experimental physiology · 2026Article
- A comparative single-cell transcriptomic atlas for diverse populations of vertebrate hair cells.bioRxiv : the preprint server for biology · 2026Article
- Type I hair cells of striolar and central zones in vestibular organs are essential for head stability and postural control.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- HSD17B7 is required for the function of sensory hair cells by regulating cholesterol synthesis.eLife · 2026Article
- Article
- Pou4f3 Deficiency Obstructs the Subtype Differentiation of Vestibular Hair Cells.Neuroscience bulletin · 2026Article
- Characterization of mouse melanocytes reveals ultrastructural and immunological insights into the inner ear function.Communications biology · 2026Article
- Tekt2 regulates hair cell development and function by maintaining normal kinocilium morphology in zebrafish.Frontiers in cell and developmental biology · 2026Article
- Revealing heterogeneity and damage response in the adult human utricle.Nature communications · 2025Article
- Reuniting and Endolymphatic Duct Macrophages: Localization and Possible Roles.Audiology research · 2025Article
- Crosstalk Signaling Between the Epithelial and Non-Epithelial Compartments of the Mouse Inner Ear.Journal of the Association for Research in Otolaryngology : JARO · 2025Article
- Development of the semicircular canals and otolithic organs of the vertebrate inner ear.Current topics in developmental biology · 2025Review
- Article
- Comparative genomic profiling of SLC26A4-expressing cells in the inner ear and other organs.PloS one · 2025Article
- Deletion of the Ebf1, a mouse deafness gene, causes a dramatic increase in hair cells and support cells of the organ of Corti.Development (Cambridge, England) · 2024Article
- Advances in single-cell transcriptomics in animal research.Journal of animal science and biotechnology · 2024Review
- 3D reconstruction of the mouse cochlea from scRNA-seq data suggests morphogen-based principles in apex-to-base specification.Developmental cell · 2024Article
- The biomedical knowledge graph of symptom phenotype in coronary artery plaque: machine learning-based analysis of real-world clinical data.BioData mining · 2024Article
- Data normalization for addressing the challenges in the analysis of single-cell transcriptomic datasets.BMC genomics · 2024Review
- scMGCN: A Multi-View Graph Convolutional Network for Cell Type Identification in scRNA-seq Data.International journal of molecular sciences · 2024Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
This study provides transcriptomic characterization of the cells of the crista ampullaris, sensory structures at the base of the semicircular canals that are critical for vestibular function. We performed single-cell RNA-seq on ampullae microdissected from E16, E18, P3, and P7 mice. Cluster analysis identified the hair cells, support cells and glia of the crista as well as dark cells and other nonsensory epithelial cells of the ampulla, mesenchymal cells, vascular cells, macrophages, and melanocytes. Cluster-specific expression of genes predicted their spatially restricted domains of gene expression in the crista and ampulla. Analysis of cellular proportions across developmental time showed dynamics in cellular composition. The new cell types revealed by single-cell RNA-seq could be important for understanding crista function and the markers identified in this study will enable the examination of their dynamics during development and disease.
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