Evidence map›Paper›PMID 34002547›Full record

Observational studyJournal of Korean medical science2021

Effect of Opioids on All-cause Mortality and Sustained Opioid Use in Elderly Patients with Hip Fracture: a Korea Nationwide Cohort Study.

Jun Il Yoo, Suk Yong Jang, Yonghan Cha, Chan Ho Park, Jung Taek Kim, Seunghak Oh, Wonsik Choy

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of Korean medical science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Jun Il Yoo *Department of Orthopaedic Surgery, Gyeongsang National University Hospital, Jinju, Korea.ORCID https://orcid.org/0000-0002-3575-4123
Suk Yong Jang *Department of Healthcare Management, Graduate School of Public Health, Yonsei University, Seoul, Korea.ORCID https://orcid.org/0000-0003-0558-1505
Yonghan ChaDepartment of Orthopaedic Surgery, Eulji University Hospital, Daejeon, Korea. naababo@hanmail.net.ORCID https://orcid.org/0000-0002-7616-6694
Chan Ho ParkDepartment of Orthopaedic Surgery, Yeungnam University Medical Center, Daegu, Korea.ORCID https://orcid.org/0000-0003-0409-8132
Jung Taek KimDepartment of Orthopaedic Surgery, Ajou Medical Center, Suwon, Korea.ORCID https://orcid.org/0000-0003-4243-5793
Seunghak OhDepartment of Orthopaedic Surgery, Eulji University Hospital, Daejeon, Korea.ORCID https://orcid.org/0000-0002-4472-6300
Wonsik ChoyDepartment of Orthopaedic Surgery, Eulji University Hospital, Daejeon, Korea.ORCID https://orcid.org/0000-0001-9020-5832
Daejeon Eulji Medical Center, Eulji University · KRAjou University · KRGyeongsang National University Hospital · KRYeungnam University Medical Center · KRYonsei University Health System · KR

Funding

Korean National Health Insurance Service NHIS-2019-2-038
6 · The paper itself

Abstract

backgroundThe purpose of our study was to assess the use of opioids before and after hip fracture in elderly patients in order to determine the effect of opioid use on all-cause mortality, and to analyze how the history of opioid use before fracture increases the risk of sustained use following hip fracture using a Korea nationwide cohort.

methodsOur study identified hip fracture patients from the Korean National Health Insurance Service-Senior cohort. The index date was defined as 90-days after admission to the acute care hospital that fulfilled the eligibility criteria of elderly hip fracture. Patients were classified into past user, current user, and sustained user according to the use of opioid at each period based on the time of admission and index date. The opioids were classified into strong opioids and tramadol. A generalized estimating equation model with a Poisson distribution and logarithmic link function was performed to estimate the adjusted rate ratios (aRRs) and 95% confidence intervals (CIs) to assess the association between past use and sustained use. A multivariable-adjusted Cox proportional hazard model was used to investigate the effects of strong opioid and tramadol use on all-cause mortality.

resultsA total of 12,927 patients were included in our study. There were 7,384 (57.12%) opioid past-users, 11,467 (88.71%) opioid current-users, and 7,172 (55.48%) sustained users. In comparison of the death risk according to current use or the defined daily dose of the opioids or past opioid use, there were no significant differences in the adjusted hazard ratio for death in all groups, compared to the current non-users (

conclusionCurrent use and past use of opioid did not increase all-cause mortality after hip fracture in elderly patients over 65 years of age. Past use of opioid before hip fracture increased risk of sustained use of opioid compared to the current opioid used without past use.

Indexed as

AgedAged, 80 and overAnalgesics, OpioidCause of DeathCohort StudiesFemaleHip FracturesHospitalizationHospital MortalityHumansMalePainPostoperative PeriodRepublic of KoreaRetrospective StudiesAnalgesics, OpioidAddictionElderlyHip FractureMortalityNationwide Cohort StudyOpioid

Identifiers

PMID34002547
PMCPMC8129618
OpenAlexW3159955706

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.