Evidence map›Paper›PMID 34002432›Full record

SynthesisThe journal of obstetrics and gynaecology research2021

Prenatal anemia and postpartum hemorrhage risk: A systematic review and meta-analysis.

Moshood O Omotayo, Ajibola I Abioye, Moshood Kuyebi, Ahizechukwu C Eke

Open access · greenAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in The journal of obstetrics and gynaecology research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 7 pooled it
23.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 7 syntheses or guidelines pooled it, 113 citations in OpenAlex.

  1. Pooled it
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  7. Prepartum Anemia and Risk of Postpartum Hemorrhage: A Meta-Analysis and Brief Review.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
    Pooled it
  8. Trial
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  10. Seventh Åland Island Meeting on von Willebrand Disease.Haemophilia : the official journal of the World Federation of Hemophilia · 2026
    Article
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  12. Review
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  20. Von Willebrand disease: more than just a bleeding disorder.Research and practice in thrombosis and haemostasis · 2026
    Review

3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 3 countries.

Moshood O OmotayoCentre for Global Health and Division of Pediatric Global Health, Massachusetts General Hospital, Boston, Massachusetts, USA.
Ajibola I AbioyeDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Moshood KuyebiDepartment of Medicine, Lagos State University Teaching Hospital, Lagos, Nigeria.
Ahizechukwu C EkeDivision of Maternal-Fetal Medicine, Department of Gynecology & Obstetrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Center for Global Health · USHarvard University Press · USJohns Hopkins Medicine · USLagos State University Teaching Hospital · NG

Funding

Understanding Medication Adherence Benchmarks, Safety and Pharmacometrics of Novel Antiretrovirals in Pregnant Women Living with HIV.K23HD104517 · NICHD · JOHNS HOPKINS UNIVERSITY · PI EKE, AHIZECHUKWU C. · 2020 to 2024
$857k
NICHD NIH HHS K23 HD104517
6 · The paper itself

Abstract

introductionPostpartum hemorrhage (PPH) has remained the leading cause of maternal mortality. While anemia is a leading contributor to maternal morbidity, molecular, cellular and anemia-induced hypoxia, clinical studies of the relationship between prenatal-anemia and PPH have reported conflicting results. Therefore, our objective was to investigate the outcomes of studies on the relationships between prenatal anemia and PPH-related mortality. MATERIALS AND

methodsElectronic databases (MEDLINE, Scopus, ClinicalTrials.gov, PROSPERO, EMBASE, and the Cochrane Central Register of Controlled Trials) were searched for studies published before August 2019. Keywords included "anemia," "hemoglobin," "postpartum hemorrhage," and "postpartum bleeding." Only studies involving the association between anemia and PPH were included in the meta-analysis. Our primary analysis used random effects models to synthesize odds-ratios (ORs) extracted from the studies. Heterogeneity was formally assessed with the Higgins' I

resultsWe found 13 eligible studies investigating the relationship between prenatal anemia and PPH. Our findings suggest that severe prenatal anemia increases PPH risk (OR = 3.54; 95% CI: 1.20, 10.4, p-value = 0.020). There was no statistical association with mild (OR = 0.60; 95% CI: 0.31, 1.17, p-value = 0.130), or moderate anemia (OR = 2.09; 95% CI: 0.40, 11.1, p-value = 0.390) and the risk of PPH.

conclusionSevere prenatal anemia is an important predictive factor of adverse outcomes, warranting intensive management during pregnancy. PROSPERO Registration Number: CRD42020149184; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=149184.

Indexed as

AnemiaOxytocicsPostpartum HemorrhageFemaleHumansMaternal MortalityPostpartum PeriodPregnancyOxytocicsmaternal mortalitymeta-analysisobstetric emergencypostpartum hemorrhage-related mortalitypostpartum hemorrhage risk factorsprenatal anemiasystematic review

Identifiers

PMID34002432
PMCPMC9258034
OpenAlexW3161134669

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.