SynthesisJournal of the Egyptian National Cancer Institute2021
The role of PI3K signaling pathway and its associated genes in papillary thyroid cancer.
Synthesis in Journal of the Egyptian National Cancer Institute, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Abstract
backgroundOne of the well-differentiated types of thyroid cancer is papillary thyroid cancer (PTC), often developed by genetic mutations and radiation.
methodsIn this study, the public NCBI-GEO database was systematically searched. The eligible datasets were the targets for biomarker discovery associated with PI3K signaling pathway.
resultsOnly two datasets were suitable and passed the inclusion criteria. The meta-analysis outcomes revealed eleven upregulation and thirteen downregulation genes differentially expressed between PTC and healthy tissues. Moreover, the outcomes for survival and disease-free rates for each gene were illustrated.
conclusionsThe present research suggests a panel signature of 24 gene biomarkers in diagnosing the PTC.
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