Evidence map›Paper›PMID 34002294›Full record

ArticleEuropean journal of epidemiology2021

Using excess deaths and testing statistics to determine COVID-19 mortalities.

Lucas Böttcher, Maria R D'Orsogna, Tom Chou

Abstract read
In one paragraph

Article in European journal of epidemiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
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  9. Observational
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  12. Article
  13. The end of the COVID-19 pandemic.European journal of clinical investigation · 2022
    Article
  14. Underestimation in Reporting Excess COVID-19 Death Data in Poland during the First Three Pandemic Waves.International journal of environmental research and public health · 2022
    Article
  15. Article
  16. A statistical model of COVID-19 testing in populations: effects of sampling bias andtesting errors.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2022
    Article
  17. On some fundamental challenges in monitoring epidemics.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2022
    Article
  18. Article
  19. Article
  20. [Response to the article: Spread of COVID-19 cases in Africa].Revista espanola de anestesiologia y reanimacion · 2021
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Lucas BöttcherDept. of Computational Medicine, UCLA, Los Angeles, CA, 90095-1766, USA.ORCID http://orcid.org/0000-0003-1700-1897
Maria R D'OrsognaDept. of Computational Medicine, UCLA, Los Angeles, CA, 90095-1766, USA.ORCID http://orcid.org/0000-0003-2828-9523
Tom ChouDept. of Computational Medicine, UCLA, Los Angeles, CA, 90095-1766, USA. tomchou@ucla.edu.ORCID http://orcid.org/0000-0003-0785-6349

Funding

Tracking clonal dynamics during hematopoiesis: mechanistic insight via modeling and data analysisR01HL146552 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHOU, TOM · 2019 to 2022
$907k
Army Research Office W911NF-18-1-0345Division of Mathematical Sciences DMS-1814090Division of Mathematical Sciences DMS-1814364NHLBI NIH HHS R01 HL146552NHLBI NIH HHS R01HL146552Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (CH) P2EZP2_191888
6 · The paper itself

Abstract

Factors such as varied definitions of mortality, uncertainty in disease prevalence, and biased sampling complicate the quantification of fatality during an epidemic. Regardless of the employed fatality measure, the infected population and the number of infection-caused deaths need to be consistently estimated for comparing mortality across regions. We combine historical and current mortality data, a statistical testing model, and an SIR epidemic model, to improve estimation of mortality. We find that the average excess death across the entire US from January 2020 until February 2021 is 9[Formula: see text] higher than the number of reported COVID-19 deaths. In some areas, such as New York City, the number of weekly deaths is about eight times higher than in previous years. Other countries such as Peru, Ecuador, Mexico, and Spain exhibit excess deaths significantly higher than their reported COVID-19 deaths. Conversely, we find statistically insignificant or even negative excess deaths for at least most of 2020 in places such as Germany, Denmark, and Norway.

Indexed as

InternationalityBiometryCOVID-19HumansSARS-CoV-2COVID-19Excess deathsMortalityTest statistics

Identifiers

PMID34002294
PMCPMC8127858

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.