SynthesisJournal of anesthesia2021
Effects of dexmedetomidine sedation for magnetic resonance imaging in children: a systematic review and meta-analysis.
Synthesis in Journal of anesthesia, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Chinese Society of Pediatric Anesthesiology Guideline for Pediatric Sedation (2025).Paediatric anaesthesia · 2026Guideline
- Effect of different intranasal dexmedetomidine doses on pediatric postoperative delirium and agitation: network meta-analysis.Pediatric research · 2025Pooled it
- An evaluation of dexmedetomidine in combination with midazolam in pediatric sedation: a systematic review and meta-analysis.BMC anesthesiology · 2024Pooled it
- Pooled it
- Effective doses of remimazolam for sedation in paediatric magnetic resonance imaging following dexmedetomidine premedication: a dose-finding study.BMC anesthesiology · 2026Trial
- Intranasal Dexmedetomidine with Propofol Provides Superior Sedation for Pediatric Contrast-Enhanced CT: A Randomized Controlled Trial.Drug design, development and therapy · 2025Trial
- Association between intranasal dexmedetomidine dose and delayed awakening after sedation in children: a retrospective cohort study.BMC anesthesiology · 2026Article
- Comparative efficacy and post-discharge adverse events of intranasal dexmedetomidine combined with different oral medications for procedural sedation in children: a randomized controlled trial.Frontiers in pharmacology · 2026Article
- A dose-ranging pilot trial of dexmedetomidine-propofol in children undergoing magnetic resonance imaging.Journal of anesthesia · 2025Article
- Remimazolam for anesthesia and sedation in pediatric patients: a scoping review.Journal of anesthesia · 2024Article
- Article
- Effects of Dexmedetomidine on Cognitive Function, Oxidative Stress and Brain Protection in Patients Undergoing Craniocerebral Surgery.Actas espanolas de psiquiatria · 2024Article
- Study on the sedative effect and safety of oral midazolam combined with dexmedetomidine nasal drops in children during magnetic resonance imaging examination.Frontiers in pediatrics · 2024Article
- Article
- Ketodex for MRI sedation in syndromic children with congenital cardiac anomalies - A case series.Indian journal of anaesthesia · 2022Article
- Effect of dexmedetomidine and propofol sedation on the prognosis of children with severe respiratory failure: a systematic review and meta-analysis.Translational pediatrics · 2022Article
- Pediatric sedation using dexmedetomidine and remimazolam for magnetic resonance imaging.Journal of anesthesia · 2022Article
- The Effectiveness of Three Regimens of Sedation for Children Undergoing Magnetic Resonance Imaging: A Clinical Study.Anesthesia, essays and researchesArticle
- Deviation from conventional anesthetics: MRI sedation with dexmedetomidine for a child with Morquio's syndrome.Medical journal, Armed Forces IndiaArticle
- Propofol-induced hiccups in MRI suite treated with dexmedetomidine.Saudi journal of anaesthesiaArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposePediatric sedation is commonly required to obtain high-quality images in magnetic resonance imaging (MRI). We performed a systematic review and meta-analysis to assess the effects of dexmedetomidine sedation for MRI in children.
methodsA systematic review was conducted to find all randomized controlled trials concerning dexmedetomidine sedation for MRI in children. We searched databases using the Ovid platform in the Cochrane Controlled Trials Register, MEDLINE, and EMBASE. This study was registered in the PROSPERO database: CRD42020198368.
resultsSeven studies and 753 participants were included. Dexmedetomidine sedation showed a significantly delayed onset time [weighted mean differences (WMD) = 8.13 min, 95% confidence interval (CI) 4.64 to 11.63, I
conclusionsDexmedetomidine sedation provided a similar sedation quality with a reduced incidence of desaturation events. However, the delayed onset and recovery times were drawbacks. The clinical significance of bradycardia is considered to be low. GRADE assessment revealed the quality of the evidence in this meta-analysis ranged from very low to moderate.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.