ArticleApplied mathematics and computation2021
Global dynamics of SARS-CoV-2/cancer model with immune responses.
Article in Applied mathematics and computation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 22 citations in OpenAlex.
- Stability of a delayed SARS-CoV-2 reactivation model with logistic growth and adaptive immune response.Physica A · 2023Article
- Stability analysis of within-host SARS-CoV-2/HIV coinfection model.Mathematical methods in the applied sciences · 2022Article
- Dynamical demeanour of SARS-CoV-2 virus undergoing immune response mechanism in COVID-19 pandemic.The European physical journal. Special topics · 2022Article
- On fractional approaches to the dynamics of a SARS-CoV-2 infection model including singular and non-singular kernels.Results in physics · 2021Article
- Analysis of the initiation of viral infection under flow conditions with applications to transmission in feed.Bio Systems · 2020Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The world is going through a critical period due to a new respiratory disease called coronavirus disease 2019 (COVID-19). This disease is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Mathematical modeling is one of the most important tools that can speed up finding a drug or vaccine for COVID-19. COVID-19 can lead to death especially for patients having chronic diseases such as cancer, AIDS, etc. We construct a new within-host SARS-CoV-2/cancer model. The model describes the interactions between six compartments: nutrient, healthy epithelial cells, cancer cells, SARS-CoV-2 virus particles, cancer-specific CTLs, and SARS-CoV-2-specific antibodies. We verify the nonnegativity and boundedness of its solutions. We outline all possible equilibrium points of the proposed model. We prove the global stability of equilibria by constructing proper Lyapunov functions. We do some numerical simulations to visualize the obtained results. According to our model, lymphopenia in COVID-19 cancer patients may worsen the outcomes of the infection and lead to death. Understanding dysfunctions in immune responses during COVID-19 infection in cancer patients could have implications for the development of treatments for this high-risk group.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.