Evidence map›Paper›PMID 34002096›Full record

SynthesisNature genetics2021

Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology.

Niamh Mullins, Andreas J Forstner, Kevin S O'Connell, Brandon Coombes, Jonathan R I Coleman, Zhen Qiao, Thomas D Als, Tim B Bigdeli, Sigrid Børte, Julien Bryois and 308 more

Registry-linked trialAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Nature genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07173842 (Establishment of the NeuroPsyBiT-BD Omics Program), which is not on this map. Cited by 930 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
930citing papers in PubMed, 9 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07173842 not yet recruitingnot on this mapstarted 2025, after this paper: background citation

Establishment of the NeuroPsyBiT-BD Omics Program: Development of a Turkish Bipolar Disorder Biobank Integrating Genomic and Epigenomic Profiling With Structured Clinical Phenotyping and Secure Data Infrastructure

Typeobservational_patient_registrySponsorSelçuk State HospitalRan2025 to 2027Enrolled1,000ConditionsBipolar DisorderArmsBiobanking and Phenotypic Data Collection
3 · Its place in the literature

Who cites it

930 citing papers in PubMed, 9 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Allele-specific expression in the brain links genetic risk and cortical thinning in psychiatric disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  20. Article

870 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

318 authors.

Niamh Mullins *Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. niamh.mullins@mssm.edu.ORCID http://orcid.org/0000-0001-8021-839X
Andreas J Forstner *Institute of Human Genetics, University of Bonn, School of Medicine and University Hospital Bonn, Bonn, Germany.
Kevin S O'ConnellDivision of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
Brandon CoombesDepartment of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
Jonathan R I ColemanSocial, Genetic and Developmental Psychiatry Centre, King's College London, London, UK.
Zhen QiaoInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.
Thomas D AlsiSEQ, Center for Integrative Sequencing, Aarhus University, Aarhus, Denmark.
Tim B BigdeliDepartment of Psychiatry and Behavioral Sciences, SUNY Downstate Health Sciences University, Brooklyn, NY, USA.
Sigrid BørteResearch and Communication Unit for Musculoskeletal Health, Division of Clinical Neuroscience, Oslo University Hospital, Oslo, Norway.
Julien BryoisDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Alexander W CharneyDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Ole Kristian DrangeDepartment of Mental Health, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.
Michael J GandalDepartment of Psychiatry and Biobehavioral Science, Semel Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Saskia P HagenaarsSocial, Genetic and Developmental Psychiatry Centre, King's College London, London, UK.
Masashi IkedaDepartment of Psychiatry, School of Medicine, Fujita Health University, Toyoake, Japan.
Nolan KamitakiStanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA.
Minsoo KimDepartment of Psychiatry and Biobehavioral Science, Semel Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Kristi KrebsEstonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.
Georgia PanagiotaropoulouDepartment of Psychiatry and Psychotherapy, Charité - Universitätsmedizin, Berlin, Germany.
Brian M SchilderDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Laura G SloofmanDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Stacy SteinbergdeCODE Genetics/Amgen, Reykjavik, Iceland.
Vassily TrubetskoyDepartment of Psychiatry and Psychotherapy, Charité - Universitätsmedizin, Berlin, Germany.
Bendik S WinsvoldK. G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.
Hong-Hee WonSamsung Advanced Institute for Health Sciences and Technology (SAIHST), Samsung Medical Center, Sungkyunkwan University, Seoul, South Korea.
Liliya AbramovaRussian Academy of Medical Sciences, Mental Health Research Center, Moscow, Russian Federation.
Kristina AdorjanInstitute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany.
Esben AgerboiPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
Mariam Al EissaDivision of Psychiatry, University College London, London, UK.
Diego AlbaniDepartment of Neuroscience, Istituto Di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy.
Ney Alliey-RodriguezDepartment of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL, USA.
Adebayo AnjorinPsychiatry, Berkshire Healthcare NHS Foundation Trust, Bracknell, UK.
Verneri AntillaAnalytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.
Anastasia Antoniou2nd Department of Psychiatry, Attikon General Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Swapnil AwasthiDepartment of Psychiatry and Psychotherapy, Charité - Universitätsmedizin, Berlin, Germany.
Ji Hyun BaekDepartment of Psychiatry, Samsung Medical Center, School of Medicine, Sungkyunkwan University, Seoul, South Korea.
Marie Bækvad-HanseniPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
Nicholas BassDivision of Psychiatry, University College London, London, UK.
Michael BauerDepartment of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Eva C BeinsInstitute of Human Genetics, University of Bonn, School of Medicine and University Hospital Bonn, Bonn, Germany.
Sarah E BergenDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Armin BirnerDepartment of Psychiatry and Psychotherapeutic Medicine, Medical University of Graz, Graz, Austria.
Carsten Bøcker PederseniPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
Erlend BøenDepartment of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway.
Marco P BoksPsychiatry, Brain Center UMC Utrecht, Utrecht, the Netherlands.
Rosa BoschInstituto de Salud Carlos III, Biomedical Network Research Centre on Mental Health (CIBERSAM), Madrid, Spain.
Murielle BrumDepartment of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt am Main, Germany.
Ben M BrumptonK. G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.
Nathalie Brunkhorst-KanaanDepartment of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt am Main, Germany.
Monika BuddeInstitute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany.
Jonas Bybjerg-GrauholmiPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
William ByerleyPsychiatry, University of California San Francisco, San Francisco, CA, USA.
Murray CairnsUniversity of Newcastle, Newcastle, New South Wales, Australia.
Miquel CasasInstituto de Salud Carlos III, Biomedical Network Research Centre on Mental Health (CIBERSAM), Madrid, Spain.
Pablo CervantesMood Disorders Program, Department of Psychiatry, McGill University Health Center, Montreal, Quebec, Canada.
Toni-Kim ClarkeDivision of Psychiatry, University of Edinburgh, Edinburgh, UK.
Cristiana CruceanuMood Disorders Program, Department of Psychiatry, McGill University Health Center, Montreal, Quebec, Canada.
Alfredo Cuellar-BarbozaDepartment of Psychiatry, Universidad Autonoma de Nuevo Leon, Monterrey, Mexico.
Julie CunninghamDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
David CurtisCentre for Psychiatry, Queen Mary University of London, London, UK.
Piotr M CzerskiDepartment of Psychiatry, Laboratory of Psychiatric Genetics, Poznan University of Medical Sciences, Poznan, Poland.
Anders M DaleCenter for Multimodal Imaging and Genetics, Departments of Neurosciences, Radiology, and Psychiatry, University of California, San Diego, CA, USA.
Nina DalknerDepartment of Psychiatry and Psychotherapeutic Medicine, Medical University of Graz, Graz, Austria.
Friederike S DavidInstitute of Human Genetics, University of Bonn, School of Medicine and University Hospital Bonn, Bonn, Germany.
Franziska DegenhardtInstitute of Human Genetics, University of Bonn, School of Medicine and University Hospital Bonn, Bonn, Germany.
Srdjan DjurovicDepartment of Medical Genetics, Oslo University Hospital, Oslo, Norway.
Amanda L DobbynDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Athanassios Douzenis2nd Department of Psychiatry, Attikon General Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Torbjørn ElvsåshagenInstitute of Clinical Medicine, University of Oslo, Oslo, Norway.
Valentina Escott-PriceMedical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK.
I Nicol FerrierAcademic Psychiatry, Newcastle University, Newcastle upon Tyne, UK.
Alessia FiorentinoDivision of Psychiatry, University College London, London, UK.
Tatiana M ForoudDepartment of Medical and Molecular Genetics, Indiana University, Indianapolis, IN, USA.
Liz FortyMedical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK.
Josef FrankDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Oleksandr FreiDivision of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
Nelson B FreimerDepartment of Psychiatry and Biobehavioral Science, Semel Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Louise FrisénDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Katrin GadeInstitute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany.
Julie GarnhamDepartment of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.
Joel GelernterDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.
Marianne Giørtz PederseniPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
Ian R GizerDepartment of Psychological Sciences, University of Missouri, Columbia, MO, USA.
Scott D GordonGenetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Katherine Gordon-SmithPsychological Medicine, University of Worcester, Worcester, UK.
Tiffany A GreenwoodDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Jakob GroveiSEQ, Center for Integrative Sequencing, Aarhus University, Aarhus, Denmark.
José Guzman-ParraMental Health Department, University Regional Hospital, Biomedicine Institute (IBIMA), Málaga, Spain.
Kyooseob HaDepartment of Psychiatry, Seoul National University College of Medicine, Seoul, South Korea.
Magnus HaraldssonLandspitali University Hospital, Reykjavik, Iceland.
Martin HautzingerDepartment of Psychology, Eberhard Karls Universität Tübingen, Tübingen, Germany.
Urs HeilbronnerInstitute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany.
Dennis HellgrenDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Stefan HermsInstitute of Human Genetics, University of Bonn, School of Medicine and University Hospital Bonn, Bonn, Germany.
Per HoffmannInstitute of Human Genetics, University of Bonn, School of Medicine and University Hospital Bonn, Bonn, Germany.
Peter A HolmansMedical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK.
Laura HuckinsDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Stéphane JamainNeuropsychiatrie Translationnelle, Inserm U955, Créteil, France.
Jessica S JohnsonDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Janos L KalmanInstitute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany.
Yoichiro KamataniLaboratory of Complex Trait Genomics, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan.
James L KennedyCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
Sarah Kittel-SchneiderDepartment of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt am Main, Germany.
James A KnowlesCell Biology, SUNY Downstate Medical Center College of Medicine, Brooklyn, NY, USA.
Manolis KogevinasISGlobal, Barcelona, Spain.
Maria KorominaLaboratory of Pharmacogenomics and Individualized Therapy, Department of Pharmacy, School of Health Sciences, University of Patras, Patras, Greece.
Thorsten M KranzDepartment of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt am Main, Germany.
Henry R KranzlerMental Illness Research, Education and Clinical Center, Crescenz VAMC, Philadelphia, PA, USA.
Michiaki KuboRIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Ralph KupkaPsychiatry, Altrecht, Utrecht, the Netherlands.
Steven A KushnerDepartment of Psychiatry, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Catharina LavebrattDepartment of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
Jacob LawrencePsychiatry, North East London NHS Foundation Trust, Ilford, UK.
Markus LeberClinic for Psychiatry and Psychotherapy, University Hospital Cologne, Cologne, Germany.
Heon-Jeong LeeDepartment of Psychiatry, Korea University College of Medicine, Seoul, South Korea.
Phil H LeePsychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Shawn E LevyHudsonAlpha Institute for Biotechnology, Huntsville, AL, USA.
Catrin LewisMedical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK.
Calwing LiaoDepartment of Human Genetics, McGill University, Montréal, Quebec, Canada.
Susanne LucaeDepartment of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany.
Martin LundbergDepartment of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
Donald J MacIntyreDivision of Psychiatry, Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, UK.
Sigurdur H MagnussondeCODE Genetics/Amgen, Reykjavik, Iceland.
Wolfgang MaierDepartment of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany.
Adam MaihoferDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Dolores MalaspinaDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Eirini MaratouClinical Biochemistry Laboratory, Attikon General Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Lina MartinssonDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Manuel MattheiseniSEQ, Center for Integrative Sequencing, Aarhus University, Aarhus, Denmark.
Steven A McCarrollStanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA.
Nathaniel W McGregorSystems Genetics Working Group, Department of Genetics, Stellenbosch University, Stellenbosch, South Africa.
Peter McGuffinSocial, Genetic and Developmental Psychiatry Centre, King's College London, London, UK.
James D McKayGenetic Cancer Susceptibility Group, International Agency for Research on Cancer, Lyon, France.
Helena MedeirosInstitute for Genomic Health, SUNY Downstate Medical Center College of Medicine, Brooklyn, NY, USA.
Sarah E MedlandGenetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Vincent MillischerDepartment of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
Grant W MontgomeryInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.
Jennifer L MoranStanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA.
Derek W MorrisCentre for Neuroimaging and Cognitive Genomics (NICOG), National University of Ireland Galway, Galway, Ireland.
Thomas W MühleisenInstitute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Jülich, Germany.
Niamh O'BrienDivision of Psychiatry, University College London, London, UK.
Claire O'DonovanDepartment of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.
Loes M Olde LoohuisDepartment of Psychiatry and Biobehavioral Science, Semel Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Lilijana OrucMedical Faculty, School of Science and Technology, University Sarajevo, Sarajevo, Bosnia and Herzegovina.
Sergi PapiolInstitute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany.
Antonio F PardiñasMedical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK.
Amy PerryPsychological Medicine, University of Worcester, Worcester, UK.
Andrea PfennigDepartment of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Evgenia Porichi2nd Department of Psychiatry, Attikon General Hospital, National and Kapodistrian University of Athens, Athens, Greece.
James B PotashDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Digby QuestedOxford Health NHS Foundation Trust, Warneford Hospital, Oxford, UK.
Towfique RajDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Mark H RapaportDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.
J Raymond DePauloDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Eline J RegeerOutpatient Clinic for Bipolar Disorder, Altrecht, Utrecht, the Netherlands.
John P RiceDepartment of Psychiatry, Washington University in Saint Louis, Saint Louis, MO, USA.
Fabio RivasMental Health Department, University Regional Hospital, Biomedicine Institute (IBIMA), Málaga, Spain.
Margarita RiveraDepartment of Biochemistry and Molecular Biology II, Faculty of Pharmacy, University of Granada, Granada, Spain.
Julian RothDepartment of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital Würzburg, Würzburg, Germany.
Panos RoussosDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Douglas M RuderferMedicine, Psychiatry, Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.
Cristina Sánchez-MoraInstituto de Salud Carlos III, Biomedical Network Research Centre on Mental Health (CIBERSAM), Madrid, Spain.
Eva C SchulteInstitute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany.
Fanny SennerInstitute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany.
Sally SharpDivision of Psychiatry, University College London, London, UK.
Paul D ShillingDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Engilbert SigurdssonLandspitali University Hospital, Reykjavik, Iceland.
Lea SirignanoDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Claire SlaneyDepartment of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.
Olav B SmelandDivision of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
Daniel J SmithInstitute of Health and Wellbeing, University of Glasgow, Glasgow, UK.
Janet L SobellPsychiatry and the Behavioral Sciences, University of Southern California, Los Angeles, CA, USA.
Christine Søholm HanseniPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
Maria Soler ArtigasInstituto de Salud Carlos III, Biomedical Network Research Centre on Mental Health (CIBERSAM), Madrid, Spain.
Anne T SpijkerMood Disorders, PsyQ, Rotterdam, the Netherlands.
Dan J SteinSAMRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
John S StraussCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
Beata ŚwiątkowskaDepartment of Environmental Epidemiology, Nofer Institute of Occupational Medicine, Lodz, Poland.
Chikashi TeraoLaboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Thorgeir E ThorgeirssondeCODE Genetics/Amgen, Reykjavik, Iceland.
Claudio TomaNeuroscience Research Australia, Sydney, New South Wales, Australia.
Paul TooneyUniversity of Newcastle, Newcastle, New South Wales, Australia.
Evangelia-Eirini TsermpiniLaboratory of Pharmacogenomics and Individualized Therapy, Department of Pharmacy, School of Health Sciences, University of Patras, Patras, Greece.
Marquis P VawterDepartment of Psychiatry and Human Behavior, School of Medicine, University of California, Irvine, Irvine, CA, USA.
Helmut VedderPsychiatry, Psychiatrisches Zentrum Nordbaden, Wiesloch, Germany.
James T R WaltersMedical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK.
Stephanie H WittDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Simon XiComputational Sciences Center of Emphasis, Pfizer Global Research and Development, Cambridge, MA, USA.
Wei XuDalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.
Jessica Mei Kay YangMedical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK.
Allan H YoungDepartment of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Hannah YoungDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Peter P ZandiDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Hang ZhouDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.
Lea ZillichDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
HUNT All-In Psychiatry
Rolf AdolfssonDepartment of Clinical Sciences, Psychiatry, Umeå University Medical Faculty, Umeå, Sweden.
Ingrid AgartzDepartment of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway.
Martin AldaDepartment of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.
Lars AlfredssonInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Gulja BabadjanovaInstitute of Pulmonology, Russian State Medical University, Moscow, Russian Federation.
Lena BacklundDepartment of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
Bernhard T BauneDepartment of Psychiatry, University of Münster, Münster, Germany.
Frank BellivierUniversité de Paris, INSERM, Optimisation Thérapeutique en Neuropsychopharmacologie, UMRS 1144, Paris, France.
Susanne BengesserDepartment of Psychiatry and Psychotherapeutic Medicine, Medical University of Graz, Graz, Austria.
Wade H BerrettiniPsychiatry, University of Pennsylvania, Philadelphia, PA, USA.
Douglas H R BlackwoodDivision of Psychiatry, University of Edinburgh, Edinburgh, UK.
Michael BoehnkeCenter for Statistical Genetics and Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.
Anders D BørglumiPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
Gerome BreenSocial, Genetic and Developmental Psychiatry Centre, King's College London, London, UK.
Vaughan J CarrSchool of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia.
Stanley CattsUniversity of Queensland, Brisbane, Queensland, Australia.
Aiden CorvinNeuropsychiatric Genetics Research Group, Department of Psychiatry and Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland.
Nicholas CraddockMedical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK.
Udo DannlowskiDepartment of Psychiatry, University of Münster, Münster, Germany.
Dimitris Dikeos1st Department of Psychiatry, Eginition Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Tõnu EskoDepartment of Genetics, Harvard Medical School, Boston, MA, USA.
Bruno EtainUniversité de Paris, INSERM, Optimisation Thérapeutique en Neuropsychopharmacologie, UMRS 1144, Paris, France.
Panagiotis FerentinosSocial, Genetic and Developmental Psychiatry Centre, King's College London, London, UK.
Mark FryeDepartment of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA.
Janice M FullertonNeuroscience Research Australia, Sydney, New South Wales, Australia.
Micha GawlikDepartment of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital Würzburg, Würzburg, Germany.
Elliot S GershonDepartment of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL, USA.
Fernando S GoesDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Melissa J GreenNeuroscience Research Australia, Sydney, New South Wales, Australia.
Maria Grigoroiu-SerbanescuBiometric Psychiatric Genetics Research Unit, Alexandru Obregia Clinical Psychiatric Hospital, Bucharest, Romania.
Joanna HauserDepartment of Psychiatry, Laboratory of Psychiatric Genetics, Poznan University of Medical Sciences, Poznan, Poland.
Frans HenskensUniversity of Newcastle, Newcastle, New South Wales, Australia.
Jan HillertDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Kyung Sue HongDepartment of Psychiatry, Samsung Medical Center, School of Medicine, Sungkyunkwan University, Seoul, South Korea.
David M HougaardiPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
Christina M HultmanDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Kristian HveemK. G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.
Nakao IwataDepartment of Psychiatry, School of Medicine, Fujita Health University, Toyoake, Japan.
Assen V JablenskyUniversity of Western Australia, Nedlands, Western Australia, Australia.
Ian JonesMedical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK.
Lisa A JonesPsychological Medicine, University of Worcester, Worcester, UK.
René S KahnDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
John R KelsoeDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
George KirovMedical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK.
Mikael LandénDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Marion LeboyerNeuropsychiatrie Translationnelle, Inserm U955, Créteil, France.
Cathryn M LewisSocial, Genetic and Developmental Psychiatry Centre, King's College London, London, UK.
Qingqin S LiNeuroscience Therapeutic Area, Janssen Research and Development, LLC, Titusville, NJ, USA.
Jolanta LissowskaCancer Epidemiology and Prevention, M. Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland.
Christine LochnerSA MRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry, Stellenbosch University, Stellenbosch, South Africa.
Carmel LoughlandUniversity of Newcastle, Newcastle, New South Wales, Australia.
Nicholas G MartinGenetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Carol A MathewsDepartment of Psychiatry and Genetics Institute, University of Florida, Gainesville, FL, USA.
Fermin MayoralMental Health Department, University Regional Hospital, Biomedicine Institute (IBIMA), Málaga, Spain.
Susan L McElroyResearch Institute, Lindner Center of HOPE, Mason, OH, USA.
Andrew M McIntoshDivision of Psychiatry, Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, UK.
Francis J McMahonHuman Genetics Branch, Intramural Research Program, National Institute of Mental Health, Bethesda, MD, USA.
Ingrid MelleDivision of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
Patricia MichieUniversity of Newcastle, Newcastle, New South Wales, Australia.
Lili MilaniEstonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.
Philip B MitchellSchool of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia.
Gunnar MorkenDepartment of Mental Health, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.
Ole MorsiPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
Preben Bo MortenseniSEQ, Center for Integrative Sequencing, Aarhus University, Aarhus, Denmark.
Bryan MowryUniversity of Queensland, Brisbane, Queensland, Australia.
Bertram Müller-MyhsokDepartment of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany.
Richard M MyersHudsonAlpha Institute for Biotechnology, Huntsville, AL, USA.
Benjamin M NealeStanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA.
Caroline M NievergeltDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Merete NordentoftiPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
Markus M NöthenInstitute of Human Genetics, University of Bonn, School of Medicine and University Hospital Bonn, Bonn, Germany.
Michael C O'DonovanMedical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK.
Ketil J OedegaardDivision of Psychiatry, Haukeland Universitetssjukehus, Bergen, Norway.
Tomas OlssonDepartment of Clinical Neuroscience and Center for Molecular Medicine, Karolinska Institutet at Karolinska University Hospital, Solna, Sweden.
Michael J OwenMedical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK.
Sara A PacigaHuman Genetics and Computational Biomedicine, Pfizer Global Research and Development, Groton, CT, USA.
Chris PantelisUniversity of Melbourne, Melbourne, Victoria, Australia.
Carlos PatoInstitute for Genomic Health, SUNY Downstate Medical Center College of Medicine, Brooklyn, NY, USA.
Michele T PatoInstitute for Genomic Health, SUNY Downstate Medical Center College of Medicine, Brooklyn, NY, USA.
George P PatrinosLaboratory of Pharmacogenomics and Individualized Therapy, Department of Pharmacy, School of Health Sciences, University of Patras, Patras, Greece.
Roy H PerlisPsychiatry, Harvard Medical School, Boston, MA, USA.
Danielle PosthumaDepartment of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
Josep Antoni Ramos-QuirogaInstituto de Salud Carlos III, Biomedical Network Research Centre on Mental Health (CIBERSAM), Madrid, Spain.
Andreas ReifDepartment of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt am Main, Germany.
Eva Z ReininghausDepartment of Psychiatry and Psychotherapeutic Medicine, Medical University of Graz, Graz, Austria.
Marta RibasésInstituto de Salud Carlos III, Biomedical Network Research Centre on Mental Health (CIBERSAM), Madrid, Spain.
Marcella RietschelDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Stephan RipkeStanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA.
Guy A RouleauMontreal Neurological Institute and Hospital, McGill University, Montréal, Quebec, Canada.
Takeo SaitoDepartment of Psychiatry, School of Medicine, Fujita Health University, Toyoake, Japan.
Ulrich SchallUniversity of Newcastle, Newcastle, New South Wales, Australia.
Martin SchallingDepartment of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
Peter R SchofieldNeuroscience Research Australia, Sydney, New South Wales, Australia.
Thomas G SchulzeInstitute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany.
Laura J ScottCenter for Statistical Genetics and Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.
Rodney J ScottUniversity of Newcastle, Newcastle, New South Wales, Australia.
Alessandro SerrettiDepartment of Biomedical and NeuroMotor Sciences, University of Bologna, Bologna, Italy.
Cynthia Shannon WeickertNeuroscience Research Australia, Sydney, New South Wales, Australia.
Jordan W SmollerStanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA.
Hreinn StefanssondeCODE Genetics/Amgen, Reykjavik, Iceland.
Kari StefanssondeCODE Genetics/Amgen, Reykjavik, Iceland.
Eystein StordalDepartment of Psychiatry, Hospital Namsos, Namsos, Norway.
Fabian StreitDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Patrick F SullivanDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Gustavo TureckiDepartment of Psychiatry, McGill University, Montreal, Quebec, Canada.
Arne E VaalerDepartment of Psychiatry, Sankt Olavs Hospital Universitetssykehuset i Trondheim, Trondheim, Norway.
Eduard VietaClinical Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Spain.
John B VincentCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
Irwin D WaldmanDepartment of Psychology, Emory University, Atlanta, GA, USA.
Thomas W WeickertNeuroscience Research Australia, Sydney, New South Wales, Australia.
Thomas WergeiPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
Naomi R WrayInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.
John-Anker ZwartInstitute of Clinical Medicine, University of Oslo, Oslo, Norway.
Joanna M BiernackaDepartment of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
John I NurnbergerPsychiatry, Indiana University School of Medicine, Indianapolis, IN, USA.
Sven CichonInstitute of Human Genetics, University of Bonn, School of Medicine and University Hospital Bonn, Bonn, Germany.
Howard J EdenbergDepartment of Medical and Molecular Genetics, Indiana University, Indianapolis, IN, USA.
Eli A StahlDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Andrew McQuillinDivision of Psychiatry, University College London, London, UK.
Arianna Di FlorioMedical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK.
Roel A OphoffDepartment of Psychiatry and Biobehavioral Science, Semel Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Ole A AndreassenDivision of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway. ole.andreassen@medisin.uio.no.ORCID http://orcid.org/0000-0002-4461-3568

Funding

Identification of Genes Involved in Major Mood DisordersZIAMH002843 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI MCMAHON, FRANCIS J · 2009 to 2025
$24.5M
African Ancestry Genomic Psychiatry CohortR01MH104964 · NIMH · SUNY DOWNSTATE MEDICAL CENTER · PI BIGDELI, TIM BERNARD, FANOUS, AYMAN H · 2015 to 2024
$16.7M
Genomic Psychiatry CohortR01MH085548 · NIMH · UNIVERSITY OF SOUTHERN CALIFORNIA · PI PATO, CARLOS N, PATO, MICHELE T · 2008 to 2012
$16.3M
Latino Ancestry Genomic Psychiatry CohortR01MH123451 · NIMH · SUNY DOWNSTATE MEDICAL CENTER · PI BIGDELI, TIM BERNARD, FANOUS, AYMAN H · 2020 to 2025
$7.1M
1/7 Psychiatric Genomics Consortium: Finding actionable variationU01MH109528 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SULLIVAN, PATRICK F · 2016 to 2020
$2.5M
Comprehensive analysis of genetic pleiotropy in eleven neuropsychiatric disordersR01MH119243 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI LEE, PHIL H. · 2020 to 2024
$2.3M
Big Omics Data Engine 2 SupercomputerS10OD026880 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KOVATCH, PATRICIA · 2019 to 2019
$2.0M
Transforming Genomics with 5 PB Big Omics Data Engine Cray CS300-AC SupercomputerS10OD018522 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KOVATCH, PATRICIA · 2014 to 2014
$1.9M
1/4 Psychiatric GWAS Consortium: Genomic Follow-up Next-Gen Sequencing & GenotypiU01MH094421 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SULLIVAN, PATRICK F · 2012 to 2015
$1.9M
1/5-The Psychiatric GWAS Consortium: Integrated & Coordinated GWAS Meta-AnalysesU01MH085520 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SULLIVAN, PATRICK F · 2008 to 2008
$642k
Medical Research Council G0801418Medical Research Council G1000708Medical Research Council MR/L010305/1Medical Research Council MR/S015132/1Medical Research Council MR/T04604X/1NIH HHS S10 OD018522NIH HHS S10 OD026880NIMH NIH HHS R01 MH085548NIMH NIH HHS R01 MH104964NIMH NIH HHS R01 MH119243NIMH NIH HHS R01 MH123451NIMH NIH HHS U01 MH085520NIMH NIH HHS U01 MH094421NIMH NIH HHS U01 MH109528World Health Organization 001
6 · The paper itself

Abstract

Bipolar disorder is a heritable mental illness with complex etiology. We performed a genome-wide association study of 41,917 bipolar disorder cases and 371,549 controls of European ancestry, which identified 64 associated genomic loci. Bipolar disorder risk alleles were enriched in genes in synaptic signaling pathways and brain-expressed genes, particularly those with high specificity of expression in neurons of the prefrontal cortex and hippocampus. Significant signal enrichment was found in genes encoding targets of antipsychotics, calcium channel blockers, antiepileptics and anesthetics. Integrating expression quantitative trait locus data implicated 15 genes robustly linked to bipolar disorder via gene expression, encoding druggable targets such as HTR6, MCHR1, DCLK3 and FURIN. Analyses of bipolar disorder subtypes indicated high but imperfect genetic correlation between bipolar disorder type I and II and identified additional associated loci. Together, these results advance our understanding of the biological etiology of bipolar disorder, identify novel therapeutic leads and prioritize genes for functional follow-up studies.

Indexed as

Genome-Wide Association StudyBipolar DisorderCase-Control StudiesChromosomes, HumanGenetic Predisposition to DiseaseGenome, HumanHumansMajor Histocompatibility ComplexMultifactorial InheritancePhenotypeQuantitative Trait LociRisk Factors

Identifiers

PMID34002096
PMCPMC8192451

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.