ReviewNature ecology & evolution2021
Towards an ecosystem model of infectious disease.
Review in Nature ecology & evolution, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 53 citations in OpenAlex.
- Excess Precipitation in Early Growing Season Increases Pathogen Pressure in Semiarid Grassland Ecosystem.Integrative zoology · 2026Article
- Regional heterogeneity of spatial-temporal characteristics and meteorological-environmental driving factors of hemorrhagic fever with renal syndrome in China.One health (Amsterdam, Netherlands) · 2026Article
- Tracking pathogen-related markers with eDNA in natural areas: how environmental factors shape surveillance strategies.Veterinary research · 2026Article
- Review
- Modelling tick abundance and environmental suitability in meso-Mediterranean landscapes for the prevention of tick-borne diseases.PLoS neglected tropical diseases · 2025Article
- Individual variation within parasite communities of endangered African lions.Royal Society open science · 2025Article
- The importance of epistasis in the evolution of viral pathogens.Virus evolution · 2025Review
- Warming effects on the life cycles of two parasitic copepods with different invasion histories.Ecology and evolution · 2024Article
- Natural History Studies, a Natural Next Step to Study Emerging Transfusion-Transmitted Infections.Transfusion medicine reviews · 2024Article
- Host-, Environment-, or Human-Related Effects Drive Interspecies Interactions in an Animal Tuberculosis Multi-Host Community Depending on the Host and Season.Transboundary and emerging diseases · 2024Article
- Ecological Strategies for Resource Use by Three Bromoviruses in Anthropic and Wild Plant Communities.Viruses · 2023Article
- Adapting modeling and simulation credibility standards to computational systems biology.Journal of translational medicine · 2023Review
- A Review of Circumpolar Arctic Marine Mammal Health-A Call to Action in a Time of Rapid Environmental Change.Pathogens (Basel, Switzerland) · 2023Review
- Standards, dissemination, and best practices in systems biology.Current opinion in biotechnology · 2023Review
- Associations between ecological diversity and rodent plague circulation in Yunnan Province, China, 1983-2020: A data-informed modelling study.PLoS neglected tropical diseases · 2023Article
- Monkeypox: a review of epidemiological modelling studies and how modelling has led to mechanistic insight.Epidemiology and infection · 2023Review
- Host-Pathogen Interactions Influencing Zoonotic Spillover Potential and Transmission in Humans.Viruses · 2023Review
- Managing host-parasite interactions in humans and wildlife in times of global change.Parasitology research · 2022Review
- A strategy to assess spillover risk of bat SARS-related coronaviruses in Southeast Asia.Nature communications · 2022Article
- Challenges in modelling the dynamics of infectious diseases at the wildlife-human interface.Epidemics · 2021Review
Corrections and comments
- Erratum issued
Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Increasingly intimate associations between human society and the natural environment are driving the emergence of novel pathogens, with devastating consequences for humans and animals alike. Prior to emergence, these pathogens exist within complex ecological systems that are characterized by trophic interactions between parasites, their hosts and the environment. Predicting how disturbance to these ecological systems places people and animals at risk from emerging pathogens-and the best ways to manage this-remains a significant challenge. Predictive systems ecology models are powerful tools for the reconstruction of ecosystem function but have yet to be considered for modelling infectious disease. Part of this stems from a mistaken tendency to forget about the role that pathogens play in structuring the abundance and interactions of the free-living species favoured by systems ecologists. Here, we explore how developing and applying these more complete systems ecology models at a landscape scale would greatly enhance our understanding of the reciprocal interactions between parasites, pathogens and the environment, placing zoonoses in an ecological context, while identifying key variables and simplifying assumptions that underly pathogen host switching and animal-to-human spillover risk. As well as transforming our understanding of disease ecology, this would also allow us to better direct resources in preparation for future pandemics.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.