ArticleGene therapy2023
Advantages of robotic assistance over a manual approach in simulated subretinal injections and its relevance for gene therapy.
Article in Gene therapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Sharper vision, steady hands: can robots improve subretinal drug delivery? Systematic review.Journal of robotic surgery · 2024Pooled it
- SS-OCT-guided dual-arm master-slave robotic system for in vivo subretinal injection in porcine eyes.Journal of robotic surgery · 2026Article
- Robot-assisted ophthalmic surgery: research trends, collaboration networks, and emerging clinical frontiers.Journal of robotic surgery · 2026Review
- Global research trends in robot-assisted vitreoretinal surgery: a visualized bibliometric analysis.Journal of robotic surgery · 2026Review
- A novel robot-assisted subretinal injection system: preliminary validation in ex vivo porcine eyes.Journal of robotic surgery · 2025Article
- Embodied artificial intelligence in ophthalmology.NPJ digital medicine · 2025Review
- Real-time Deformation-aware Control for Autonomous Robotic Subretinal Injection under iOCT Guidance.IEEE International Conference on Robotics and Automation : ICRA : [proceedings]. IEEE International Conference on Robotics and Automation · 2025Article
- A non-surgical method for subretinal delivery by trans-scleral microneedle injection.Bioengineering & translational medicine · 2025Article
- Head-mounted surgical robots are an enabling technology for subretinal injections.Science robotics · 2025Article
- Advances in technical methods and applications of subretinal injections in experimental animals.Frontiers in veterinary science · 2025Review
- Artificial intelligence technology in ophthalmology public health: current applications and future directions.Frontiers in cell and developmental biology · 2025Review
- Autonomous Needle Navigation in Subretinal Injections via iOCT.IEEE robotics and automation letters · 2024Article
- Intravitreal Delivery of PEGylated-ECO Plasmid DNA Nanoparticles for Gene Therapy of Stargardt Disease.Pharmaceutical research · 2024Article
- Design of a Subretinal Injection Robot Based on the RCM Mechanism.Micromachines · 2023Article
- Microsurgery Robots: Applications, Design, and Development.Sensors (Basel, Switzerland) · 2023Review
- The Role of Subretinal Injection in Ophthalmic Surgery: Therapeutic Agent Delivery and Other Indications.International journal of molecular sciences · 2023Review
- Robot-assisted subretinal injection system: development and preliminary verification.BMC ophthalmology · 2022Article
- OCT-guided Robotic Subretinal Needle Injections: A Deep Learning-Based Registration Approach.Proceedings. IEEE International Conference on Bioinformatics and Biomedicine · 2022Article
- Robotic Assistance for Intraocular Microsurgery: Challenges and Perspectives.Proceedings of the IEEE. Institute of Electrical and Electronics Engineers · 2022Article
- Development and ex-vivo validation of 36G polyimide cannulas integrating a guiding miniaturized OCT probe for robotic assisted subretinal injections.Biomedical optics express · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Subretinal injection is a method for gene delivery to treat genetic diseases of the photoreceptors and retinal pigment epithelium. A reflux-free subretinal injection is important to allow effective, safe, and cost-effective gene therapy to the retina. We report on a comparison between manual and robotic assistance in simulated subretinal injections using an artificial retina model. Nine surgeons carried out the procedure with and without the Preceyes Surgical System, using an OPMI Lumera 700 Zeiss surgical microscope equipped with intra-operative optical coherence tomography. Success in creating a bleb without reflux, injection duration, drift, tremor, and increase in the diameter of the puncture hole were analyzed. Robotic assistance improved drift (median 16 vs 212 µm), tremor (median 1 vs 18 µm), enlargement of the retinal hole, and allowed for prolonged injection times (median 52 vs 29 sec). Robotic assistance allowed higher rate of bleb formation (8/9 vs 4/9 attempts) with a moderate reduction in reflux (7/9 vs 8/9 attempts) in this artificial model. Robotic assistance can significantly contribute to subretinal injections and provide quantifiable parameters in assessing surgical and clinical success of novel retinal gene therapies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.