Evidence map›Paper›PMID 34002043›Full record

ArticleEuropean journal of human genetics : EJHG2021

The genetic structure of Norway.

Morten Mattingsdal, S Sunna Ebenesersdóttir, Kristjan H S Moore, Ole A Andreassen, Thomas F Hansen, Thomas Werge, Ingrid Kockum, Tomas Olsson, Lars Alfredsson, Agnar Helgason and 2 more

Abstract read
In one paragraph

Article in European journal of human genetics : EJHG, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  11. Genotyping arrays, population genetic studies and clinical implications.European journal of human genetics : EJHG · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Morten MattingsdalCentre for Coastal Research, Department of Natural Sciences, University of Agder, Kristiansand, Norway. morten.mattingsdal@uia.no.ORCID 0000-0003-4440-0324
S Sunna EbenesersdóttirdeCODE Genetics/AMGEN, Inc., Reykjavik, Iceland.
Kristjan H S MooredeCODE Genetics/AMGEN, Inc., Reykjavik, Iceland.ORCID 0000-0002-9579-4362
Ole A AndreassenNORMENT, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.ORCID 0000-0002-4461-3568
Thomas F HansenInstitute of Biological Psychiatry, Copenhagen Mental Health Services, Copenhagen, Denmark.ORCID 0000-0001-6703-7762
Thomas WergeDanish Headache Center, Department of Neurology, Copenhagen University hospital, Glostrup, Denmark.ORCID 0000-0003-1829-0766
Ingrid KockumDepartment of Clinical Neuroscience, Center for Molecular Medicine, Neuroimmunology Unit, Karolinska Institutet, Stockholm, Sweden.
Tomas OlssonDepartment of Clinical Neuroscience, Center for Molecular Medicine, Neuroimmunology Unit, Karolinska Institutet, Stockholm, Sweden.
Lars AlfredssonInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0003-1688-6697
Agnar HelgasondeCODE Genetics/AMGEN, Inc., Reykjavik, Iceland.
Kári StefánssondeCODE Genetics/AMGEN, Inc., Reykjavik, Iceland.
Eivind HovigCenter for Bioinformatics, Department of Informatics, University of Oslo, Oslo, Norway. ehovig@ifi.uio.no.ORCID 0000-0002-9103-1077

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of the present study was to describe the genetic structure of the Norwegian population using genotypes from 6369 unrelated individuals with detailed information about places of residence. Using standard single marker- and haplotype-based approaches, we report evidence of two regions with distinctive patterns of genetic variation, one in the far northeast, and another in the south of Norway, as indicated by fixation indices, haplotype sharing, homozygosity, and effective population size. We detect and quantify a component of Uralic Sami ancestry that is enriched in the North. On a finer scale, we find that rates of migration have been affected by topography like mountain ridges. In the broader Scandinavian context, we detect elevated relatedness between the mid- and northern border areas towards Sweden. The main finding of this study is that despite Norway's long maritime history and as a former Danish territory, the region closest to mainland Europe in the south appears to have been an isolated region in Norway, highlighting the open sea as a barrier to gene flow into Norway.

Indexed as

Polymorphism, GeneticHaplotypesHumansNorwayPedigreePopulation

Identifiers

PMID34002043
PMCPMC8560852

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.