Observational studyScientific reports2021
End-tidal to arterial carbon dioxide gradient is associated with increased mortality in patients with traumatic brain injury: a retrospective observational study.
Observational study in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07480655 (Evaluation of Effect of Pv-aCO2-Gap on Clinical Outcomes With Standard Resuscitation End-points in Adult Poly-trauma Patients Admitted to the ICU --- Prospective Randomized Control Trial), which is not on this map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of Effect of Pv-aCO2-Gap on Clinical Outcomes With Standard Resuscitation End-points in Adult Poly-trauma Patients Admitted to the ICU --- Prospective Randomized Control Trial
Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
- Prehospital Normoventilation in Critically Ill Anaesthetised Patients Cannot Be Reliably Monitored by Capnography-A Retrospective Observational Study.Acta anaesthesiologica Scandinavica · 2026Observational
- Service evaluation: Accuracy of using end-tidal COJournal of the Intensive Care Society · 2026Article
- Association between arterial to end-tidal carbon dioxide gradient and prehospital hemodynamic status in patients with moderate-to-severe traumatic brain injury.BMC emergency medicine · 2026Article
- Predictive Value of End-Tidal COMedicina (Kaunas, Lithuania) · 2026Observational
- Observational
- The Importance of Normocapnia in Patients With Severe Traumatic Brain Injury in Prehospital Emergency Medicine.Journal of the American College of Emergency Physicians open · 2025Article
- End-tidal carbon dioxide and arterial to end-tidal carbon dioxide gradient are associated with mortality in patients with neurological injuries.Scientific reports · 2024Article
- Individualized estimation of arterial carbon dioxide partial pressure using machine learning in children receiving mechanical ventilation.BMC pediatrics · 2024Observational
- Agreement between arterial and end-tidal carbon dioxide in adult patients admitted with serious traumatic brain injury.PloS one · 2024Article
- Pre-hospital endotracheal intubation in severe traumatic brain injury: ventilation targets and mortality-a retrospective analysis of 308 patients.Scandinavian journal of trauma, resuscitation and emergency medicine · 2023Article
- Association between prehospital end-tidal carbon dioxide levels and mortality in patients with suspected severe traumatic brain injury.Intensive care medicine · 2023Article
- End-tidal carbon dioxide tension is a reliable surrogate of arterial carbon dioxide tension across different oxygen, carbon dioxide and barometric pressures.ERJ open research · 2023Article
- Airway management in a Helicopter Emergency Medical Service (HEMS): a retrospective observational study of 365 out-of-hospital intubations.BMC emergency medicine · 2022Observational
- Diagnostic Modalities in Critical Care: Point-of-Care Approach.Diagnostics (Basel, Switzerland) · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Early definitive airway protection and normoventilation are key principles in the treatment of severe traumatic brain injury. These are currently guided by end tidal CO
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.