Evidence map›Paper›PMID 34001964›Full record

ArticleScientific reports2021

Transportation container for pre-processing cytogenetic assays in radiation accidents.

Jian Gu, Brett Duane, Mikhail Repin, David J Brenner, Frederic Zenhausern

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 58% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Jian GuCenter for Applied NanoBioscience and Medicine, Department of Basic Medical Sciences, The University of Arizona, College of Medicine, Phoenix, AZ, 85004, USA. jgu10@arizona.edu.
Brett DuaneCenter for Applied NanoBioscience and Medicine, Department of Basic Medical Sciences, The University of Arizona, College of Medicine, Phoenix, AZ, 85004, USA.
Mikhail RepinCenter for Radiological Research, Columbia University, Vagelos College of Physicians and Surgeons, New York, NY, 10032, USA.
David J BrennerCenter for Radiological Research, Columbia University, Vagelos College of Physicians and Surgeons, New York, NY, 10032, USA.
Frederic ZenhausernCenter for Applied NanoBioscience and Medicine, Department of Basic Medical Sciences, The University of Arizona, College of Medicine, Phoenix, AZ, 85004, USA. fzenhaus@arizona.edu.
University of Arizona · USColumbia University · US

Funding

Sample Engineering CoreU19AI067773 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI FORNACE, ALBERT J · 2005 to 2024
$105.4M
National Institute of Allergy and Infectious Diseases, United States 5U19AI067773NIAID NIH HHS U19 AI067773
6 · The paper itself

Abstract

We report a shipping container that enables a disruptive logistics for cytogenetic biodosimetry for radiation countermeasures through pre-processing cell culture during transportation. The container showed precise temperature control (< 0.01 °C) with uniform sample temperature (< 0.1 °C) to meet the biodosimetry assay requirements. Using an existing insulated shipping box and long shelf life alkaline batteries makes it ideal for national stockpile. Dose curve of cytogenetic biodosimetry assay using the shipping container showed clear dose response and high linear correlation with the control dose curve using a laboratory incubator (Pearson's correlation coefficient: 0.992). The container's ability of pre-processing biological samples during transportation could have a significant impact on radiation countermeasure, as well as potential impacts in other applications such as biobanking, novel molecular or cell-based assays or therapies.

Indexed as

Radioactive Hazard ReleaseBiological AssayBiological Specimen BanksCytogenetic AnalysisCytogeneticsHumansShipsSpecimen HandlingTransportation

Identifiers

PMID34001964
PMCPMC8129553
OpenAlexW3161569359

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.