Evidence map›Paper›PMID 34001909›Full record

ArticleNPJ schizophrenia2021

Increased face detection responses on the mooney faces test in people at clinical high risk for psychosis.

Steven M Silverstein, Judy L Thompson, James M Gold, Jason Schiffman, James A Waltz, Trevor F Williams, Richard E Zinbarg, Vijay A Mittal, Lauren M Ellman, Gregory P Strauss and 8 more

Open access · goldAbstract read
In one paragraph

Article in NPJ schizophrenia, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 19 citations in OpenAlex.

  1. Trial
  2. Article
  3. Environmental Exposures and Computational Mechanisms in Psychosis Risk: Insights from a Multi-Site Cohort.Clinical psychological science : a journal of the Association for Psychological Science · 2026
    Article
  4. Mismatch negativity matures in adolescence and without sensitivity to microglial depletion.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Computerized Assessment of Psychosis Risk.Journal of psychiatry and brain science · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 8 institutions in 1 country.

Steven M SilversteinUniversity of Rochester Medical Center, New York, NY, USA. steven_silverstein@urmc.rochester.edu.ORCID http://orcid.org/0000-0002-0699-0960
Judy L ThompsonUniversity of Rochester Medical Center, New York, NY, USA.
James M GoldUniversity of Maryland School of Medicine, Baltimore, MD, USA.
Jason SchiffmanUniversity of Maryland School of Medicine, Baltimore, MD, USA.
James A WaltzUniversity of Maryland School of Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-9236-3719
Trevor F WilliamsNorthwestern University, Evanston, IL, USA.
Richard E ZinbargNorthwestern University, Evanston, IL, USA.
Vijay A MittalNorthwestern University, Evanston, IL, USA.ORCID http://orcid.org/0000-0001-9017-5119
Lauren M EllmanTemple University, Philadelphia, PA, USA.
Gregory P StraussUniversity of Georgia, Athens, GA, USA.
Elaine F WalkerEmory University, Atlanta, GA, USA.
Scott W WoodsYale University, New Haven, CT, USA.
Jason A LevinUniversity of Georgia, Athens, GA, USA.ORCID http://orcid.org/0000-0002-9123-0404
Eren KafadarYale University, New Haven, CT, USA.
Joshua KenneyYale University, New Haven, CT, USA.
Dillon SmithPrinceton University, Princeton, NJ, USA.
Albert R Powers *Yale University, New Haven, CT, USA.
Philip R Corlett *Yale University, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-5368-1992
Yale University · USNorthwestern University · USUniversity of Maryland, Baltimore · USUniversity of Georgia · USUniversity of Rochester Medical Center · USEmory University · USPrinceton University · USTemple University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
2/9 - Predictors and Mechanisms of Conversion to PsychosisU01MH081988 · NIMH · EMORY UNIVERSITY · PI WALKER, ELAINE FRAN · 2008 to 2018
$5.4M
5/5 CAPER: Computerized Assessment of Psychosis RiskR01MH120089 · NIMH · YALE UNIVERSITY · PI CORLETT, PHILIP, WOODS, SCOTT W · 2020 to 2024
$3.1M
Prodromal Inventory for Negative Symptoms (PINS): A Development and Validation StudyR01MH116039 · NIMH · UNIVERSITY OF GEORGIA · PI MITTAL, VIJAY A, STRAUSS, GREGORY P · 2019 to 2023
$3.1M
1/5 CAPER: Computerized Assessment of ProdromE RiskR01MH120090 · NIMH · UNIVERSITY OF MARYLAND BALTIMORE · PI GOLD, JAMES M. · 2020 to 2024
$2.9M
4/5 CAPER: Computerized assessment of psychosis riskR01MH120092 · NIMH · UNIVERSITY OF GEORGIA · PI STRAUSS, GREGORY P · 2020 to 2024
$2.0M
2/5 CAPER Computerized assessment of psychosis riskR01MH120088 · NIMH · NORTHWESTERN UNIVERSITY · PI MITTAL, VIJAY A · 2020 to 2024
$2.0M
1/3-Community Psychosis Risk Screening: An Instrument Development Study SupplementR01MH112613 · NIMH · TEMPLE UNIV OF THE COMMONWEALTH · PI ELLMAN, LAUREN M · 2017 to 2022
$1.8M
CAPER: Computerized Assessment of Psychosis Risk SupplementR01MH120091 · NIMH · TEMPLE UNIV OF THE COMMONWEALTH · PI ELLMAN, LAUREN M · 2020 to 2024
$1.6M
Administrative Supplement - 3/3: Community Psychology Risk Screening: An Instrument Development StudyR01MH112612 · NIMH · UNIVERSITY OF MARYLAND BALTIMORE COUNTY · PI PITTS, STEVEN C, SCHIFFMAN, JASON E · 2017 to 2022
$1.3M
2/3 Community psychosis risk screening: An instrument development studyR01MH112545 · NIMH · NORTHWESTERN UNIVERSITY · PI MITTAL, VIJAY A · 2017 to 2021
$1.2M
A Hearing Test for Hallucinations: Toward Development of Computational Markers for Early DiagnosisK23MH115252 · NIMH · YALE UNIVERSITY · PI POWERS, ALBERT R · 2018 to 2022
$983k
NCATS NIH HHS UL1 TR001863NIMH NIH HHS K23 MH115252NIMH NIH HHS R01 MH112545NIMH NIH HHS R01 MH112612NIMH NIH HHS R01 MH112613NIMH NIH HHS R01 MH116039NIMH NIH HHS R01 MH120088NIMH NIH HHS R01 MH120089NIMH NIH HHS R01 MH120090NIMH NIH HHS R01 MH120091NIMH NIH HHS R01 MH120092NIMH NIH HHS R21 MH119438NIMH NIH HHS U01 MH081988
6 · The paper itself

Abstract

Identifying state-sensitive measures of perceptual and cognitive processes implicated in psychosis may allow for objective, earlier, and better monitoring of changes in mental status that are predictive of an impending psychotic episode, relative to traditional self-report-based clinical measures. To determine whether a measure of visual perception that has demonstrated sensitivity to the clinical state of schizophrenia in multiple prior studies is sensitive to features of the at-risk mental state, we examined differences between young people identified as being at clinical high risk for psychosis (CHR; n = 37) and non-psychiatric matched controls (n = 29) on the Mooney Faces Test (MFT). On each trial of the MFT, participants report whether they perceive a face in a degraded face image. The CHR group reported perceiving a greater number of faces in both upright and inverted MFT stimuli. Consistent with prior work, males reported more faces on the MFT than females in both conditions. However, the finding of greater reported face perception among CHR subjects was robustly observed in the female CHR group relative to the female control group. Among male CHR participants, greater reported face perception was related to increased perceptual abnormalities. These preliminary results are consistent with a small but growing literature suggesting that heightened perceptual sensitivity may characterize individuals at increased clinical risk for psychosis. Further studies are needed to determine the contributions of specific perceptual, cognitive, and motivational mechanisms to the findings.

Identifiers

PMID34001909
PMCPMC8129098
OpenAlexW3162245544

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.