ArticleNature communications2021
EMX2-GPR156-Gαi reverses hair cell orientation in mechanosensory epithelia.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed.
- Reply to Tarchini et al.: Evidence for a GPR156 role in central stress responses in addition to its inner-ear function.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Inner ear deficits complicate interpretation of depression-like behaviors inProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Genotype-phenotype correlation-driven precision management in hereditary conductive and mixed hearing loss.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Article
- Progressive correction of auditory hair cell orientation in the absence of core planar cell polarity and GPR156 signaling.Development (Cambridge, England) · 2026Article
- A multicellular analysis calcium imaging toolbox for ImageJ.Cell reports methods · 2026Article
- A Novel Homozygous Loss-of-Function Variant in GPR156 Delineates Non-syndromic Hearing Loss.Biochemical genetics · 2026Article
- GPR156 is required in sensory hair cells for proper auditory and vestibular function.Scientific reports · 2026Article
- Planar polarized organization of mouse hair cells is established and maintained by STK32A, GPR156 and EMX2.Journal of cell science · 2025Article
- An Integrated System for Comprehensive Mouse Peripheral Vestibular Function Evaluation Based on Vestibulo-ocular Reflex.Journal of the Association for Research in Otolaryngology : JARO · 2025Article
- Stem and progenitor cell proliferation are independently regulated by cell type-specific cyclinD genes.Nature communications · 2025Article
- Junctional force patterning drives both positional order and planar polarity in the auditory epithelia.Nature communications · 2025Article
- A force-sensitive adhesion GPCR is required for equilibrioception.Cell research · 2025Article
- Review
- Emx2 is an essential regulator of ciliated cell development across embryonic tissues.iScience · 2024Article
- Molecular insights into the activation mechanism of GPR156 in maintaining auditory function.Nature communications · 2024Article
- Instrumented swim test for quantifying motor impairment in rodents.Scientific reports · 2024Article
- Contributions of mirror-image hair cell orientation to mouse otolith organ and zebrafish neuromast function.eLife · 2024Article
- Contributions of mirror-image hair cell orientation to mouse otolith organ and zebrafish neuromast function.bioRxiv : the preprint server for biology · 2024Article
- Emx2 lineage tracing reveals antecedent patterns of planar polarity in the mouse inner ear.Development (Cambridge, England) · 2024Article
- Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Hair cells detect sound, head position or water movements when their mechanosensory hair bundle is deflected. Each hair bundle has an asymmetric architecture that restricts stimulus detection to a single axis. Coordinated hair cell orientations within sensory epithelia further tune stimulus detection at the organ level. Here, we identify GPR156, an orphan GPCR of unknown function, as a critical regulator of hair cell orientation. We demonstrate that the transcription factor EMX2 polarizes GPR156 distribution, enabling it to signal through Gαi and trigger a 180° reversal in hair cell orientation. GPR156-Gαi mediated reversal is essential to establish hair cells with mirror-image orientations in mouse otolith organs in the vestibular system and in zebrafish lateral line. Remarkably, GPR156-Gαi also instructs hair cell reversal in the auditory epithelium, despite a lack of mirror-image organization. Overall, our work demonstrates that conserved GPR156-Gαi signaling is integral to the framework that builds directional responses into mechanosensory epithelia.
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