Evidence map›Paper›PMID 34001887›Full record

ArticleNature communications2021

TRPM7 kinase-mediated immunomodulation in macrophage plays a central role in magnesium ion-induced bone regeneration.

Wei Qiao, Karen H M Wong, Jie Shen, Wenhao Wang, Jun Wu, Jinhua Li, Zhengjie Lin, Zetao Chen, Jukka P Matinlinna, Yufeng Zheng and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 171 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
171citing papers in PubMed, 2 pooled it
26.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

171 citing papers in PubMed, 2 syntheses or guidelines pooled it, 352 citations in OpenAlex.

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  17. Temporal immunomodulation of CD4Science advances · 2026
    Article
  18. [Mechanisms and applications of magnesium ion-regulated stem cell functions in promoting tendon-bone interface healing].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2026
    Review
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111 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 7 institutions in 3 countries.

Wei QiaoDepartment of Orthopaedics and Traumatology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.ORCID http://orcid.org/0000-0002-0450-0366
Karen H M WongDepartment of Orthopaedics and Traumatology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
Jie ShenDepartment of Orthopaedics and Traumatology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
Wenhao WangDepartment of Orthopaedics and Traumatology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
Jun WuDepartment of Orthopaedics and Traumatology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
Jinhua LiDepartment of Orthopaedics and Traumatology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.ORCID http://orcid.org/0000-0003-1110-7471
Zhengjie LinDepartment of Orthopaedics and Traumatology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
Zetao ChenDepartment of Oral Implantology, Hospital of Stomatology, Guanghua School of Stomatology, Institute of Stomatological Research, Sun Yat-sen University, Guangzhou, China.
Jukka P MatinlinnaDental Materials Science, Applied Oral Sciences, Faculty of Dentistry, The University of Hong Kong, Hong Kong SAR., China.
Yufeng ZhengState Key Laboratory for Turbulence and Complex System and Department of Materials Science and Engineering, College of Engineering, Peking University, Beijing, China.ORCID http://orcid.org/0000-0002-7402-9979
Shuilin WuSchool of Materials Science and Engineering, Tianjin University, Tianjin, China.
Xuanyong LiuState Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, China.
Keng Po LaiGuangxi Key Laboratory of Tumor Immunology and Microenvironmental Regulation, Guilin Medical University, Guilin, China.ORCID http://orcid.org/0000-0001-8135-6030
Zhuofan ChenZhujiang New Town Clinic, Hospital of Stomatology, Sun Yat-sen University, Guangzhou, China. chzhuof@mail.sysu.edu.cn.ORCID http://orcid.org/0000-0002-3341-1485
Yun Wah LamDepartment of Chemistry, City University of Hong Kong, Kowloon Tong, Hong Kong SAR, China. yunwlam@cityu.edu.hk.
Kenneth M C CheungDepartment of Orthopaedics and Traumatology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
Kelvin W K YeungDepartment of Orthopaedics and Traumatology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China. wkkyeung@hku.hk.ORCID http://orcid.org/0000-0003-0887-088X
University of Hong Kong - Shenzhen Hospital · CNCity University of Hong Kong · HKSun Yat-sen University · CNChinese Academy of Sciences · CNPeking University · CNTianjin University · CNUniversity of Hong Kong · HK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite the widespread observations on the osteogenic effects of magnesium ion (Mg

Indexed as

AnimalsBone RegenerationCell DifferentiationCells, CulturedCytokinesFemurGene ExpressionHumansImmunomodulationInflammationMacrophagesMagnesiumOsteoclastsOsteogenesisProtein Serine-Threonine KinasesRatsCytokinesMagnesiumProtein Serine-Threonine KinasesTRPM7 protein, humanTRPM Cation Channels

Identifiers

PMID34001887
PMCPMC8128914
OpenAlexW3161978623

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.