ArticleNature communications2021
Connectivity characterization of the mouse basolateral amygdalar complex.
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Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers.
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85 citing papers in PubMed.
- Article
- A basolateral amygdala to dorsolateral striatum projection modulates stimulus-evoked motor behavior.Neuron · 2026Article
- Early adversity promotes adolescent avoidance behavior by enhancing prefrontal-amygdala communication through CRHbioRxiv : the preprint server for biology · 2026Article
- Topographic Mesocortex-Amygdalar Projections Expand the Molecular and Functional Model of the Limbic System.Molecular neurobiology · 2026Article
- Sex differences in neural circuits driving binge-like drinking: a female-specific role for an amygdalo-striatal pathway.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Early-life stress impairs development of functional interactions and neuronal activity within prefrontal-amygdala networks in vivo.Molecular psychiatry · 2026Article
- Mapping of uterine-related neurons in central nervous system of mice byBiochemistry and biophysics reports · 2026Article
- Hyperactive basolateral amygdala mediates comorbid anxiety in chronic rhinosinusitis.Journal of neuroinflammation · 2026Article
- Sequestration of growth cone surface proteins by cytoplasmic Lrrtm2 inducesbioRxiv : the preprint server for biology · 2026Article
- Increased c-Fos expression in lateral habenula during social transmission of negative valence in prairie voles.Molecular autism · 2026Article
- Sex and Stress Govern the Function and Innervation of a Basolateral Amygdala to Nucleus Accumbens Corticotropin-Releasing Hormone/GABA-Expressing Projection.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Neural Regulation of Blood Glucose in Acute Stress: A Report on Research Supported by Pathway to Stop Diabetes.Diabetes · 2026Review
- Postnatal maturation of the basolateral and paralaminar amygdala in rodents: implications for social-emotional development.Frontiers in neuroscience · 2026Review
- An amygdala-cortical circuit for encoding generalized fear memories.Molecular psychiatry · 2026Article
- Dendritome mapping reveals the spatial organization of striatal neuron morphology.Nature neuroscience · 2025Article
- A lateralized pathway for associating nutrients with flavors.bioRxiv : the preprint server for biology · 2025Article
- Integrating Aversive Memories in the Basolateral Amygdala.Biological psychiatry · 2025Review
- A network of basolateral amygdala projection neurons contributes to stress-induced activation of the hypothalamic-pituitary-adrenal axis.Science advances · 2025Article
- Immediate-early genes Arc and c-Fos show divergent brain-wide expression following contextual fear conditioning.Communications biology · 2025Article
- Morphological and electrophysiological diversity and connectivity of principal neurons in the lateral and basal nuclei of the mouse amygdala.Scientific reports · 2025Article
25 more citing papers are in PubMed but not listed here.
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Authors and funding
34 authors.
Houri HintiryanStevens Neuroimaging and Informatics Institute, Laboratory of Neuro Imaging, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. HHintiryan@mednet.ucla.edu.ORCID 0000-0002-9721-6785
Ian BowmanStevens Neuroimaging and Informatics Institute, Laboratory of Neuro Imaging, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
David L JohnsonStevens Neuroimaging and Informatics Institute, Laboratory of Neuro Imaging, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0003-1766-8501
Laura KorobkovaStevens Neuroimaging and Informatics Institute, Laboratory of Neuro Imaging, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Muye ZhuStevens Neuroimaging and Informatics Institute, Laboratory of Neuro Imaging, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Neda KhanjaniStevens Neuroimaging and Informatics Institute, Laboratory of Neuro Imaging, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Lin GouStevens Neuroimaging and Informatics Institute, Laboratory of Neuro Imaging, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Lei GaoStevens Neuroimaging and Informatics Institute, Laboratory of Neuro Imaging, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Seita YamashitaStevens Neuroimaging and Informatics Institute, Laboratory of Neuro Imaging, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Michael S BienkowskiStevens Neuroimaging and Informatics Institute, Laboratory of Neuro Imaging, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0002-8231-8893
Luis GarciaStevens Neuroimaging and Informatics Institute, Laboratory of Neuro Imaging, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Nicholas N FosterStevens Neuroimaging and Informatics Institute, Laboratory of Neuro Imaging, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Nora L BenavidezStevens Neuroimaging and Informatics Institute, Laboratory of Neuro Imaging, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0002-7754-0991
Monica Y SongStevens Neuroimaging and Informatics Institute, Laboratory of Neuro Imaging, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Darrick LoStevens Neuroimaging and Informatics Institute, Laboratory of Neuro Imaging, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0002-5516-8607
Kaelan R CotterStevens Neuroimaging and Informatics Institute, Laboratory of Neuro Imaging, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Marlene BecerraStevens Neuroimaging and Informatics Institute, Laboratory of Neuro Imaging, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Sarvia AquinoStevens Neuroimaging and Informatics Institute, Laboratory of Neuro Imaging, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Chunru CaoStevens Neuroimaging and Informatics Institute, Laboratory of Neuro Imaging, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Ryan P CabeenStevens Neuroimaging and Informatics Institute, Laboratory of Neuro Imaging, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Jim StanisStevens Neuroimaging and Informatics Institute, Laboratory of Neuro Imaging, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Marina FayzullinaStevens Neuroimaging and Informatics Institute, Laboratory of Neuro Imaging, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Sarah A UstrellStevens Neuroimaging and Informatics Institute, Laboratory of Neuro Imaging, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Tyler BoesenStevens Neuroimaging and Informatics Institute, Laboratory of Neuro Imaging, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Amanda J TuganguiStevens Neuroimaging and Informatics Institute, Laboratory of Neuro Imaging, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Zheng-Gang ZhangZilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Bo PengZilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0001-8122-189X
Michael S FanselowBrain Research Institute, Department of Psychology, University of California, Los Angeles, CA, USA.
Peyman GolshaniDepartment of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.ORCID 0000-0002-5406-7695
Joel D HahnDepartment of Biological Sciences, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0003-4024-0247
Ian R WickershamMcGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0000-0003-0389-5324
Giorgio A AscoliKrasnow Institute for Advanced Study, George Mason University, Fairfax, VA, USA.
Li I ZhangCenter for Neural Circuitry & Sensory Processing Disorders, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Hong-Wei DongStevens Neuroimaging and Informatics Institute, Laboratory of Neuro Imaging, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. HongWeiD@mednet.ucla.edu.ORCID 0000-0001-9972-3177
Funding
Tool and Technology Development CoreU19MH114821 · NIMH · COLD SPRING HARBOR LABORATORY · PI MITRA, PARTHA PRATIM · 2017 to 2021
$64.5MTR&D3: Intrinsic Surface MappingP41EB015922 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI VAN HORN, JOHN DARRELL · 2012 to 2022
$14.1MAnatomical characterization of neuronal cell types of the mouse brainU01MH114829 · NIMH · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ASCOLI, GIORGIO A, DONG, HONG-WEI · 2017 to 2021
$13.9MThe Mouse Connectome Project Phase III: Assembling the global neural networks of the mouse brainR01MH094360 · NIMH · UNIVERSITY OF SOUTHERN CALIFORNIA · PI DONG, HONG-WEI · 2012 to 2021
$7.4MGeneration and Description of Neuronal Morphology and ConnectivityR01NS039600 · NINDS · GEORGE MASON UNIVERSITY · PI ASCOLI, GIORGIO A · 1999 to 2024
$6.9MNIBIB NIH HHS P41 EB015922NIMH NIH HHS R01 MH094360NIMH NIH HHS U01 MH114829NIMH NIH HHS U19 MH114821NINDS NIH HHS R01 NS039600
Abstract
The basolateral amygdalar complex (BLA) is implicated in behaviors ranging from fear acquisition to addiction. Optogenetic methods have enabled the association of circuit-specific functions to uniquely connected BLA cell types. Thus, a systematic and detailed connectivity profile of BLA projection neurons to inform granular, cell type-specific interrogations is warranted. Here, we apply machine-learning based computational and informatics analysis techniques to the results of circuit-tracing experiments to create a foundational, comprehensive BLA connectivity map. The analyses identify three distinct domains within the anterior BLA (BLAa) that house target-specific projection neurons with distinguishable morphological features. We identify brain-wide targets of projection neurons in the three BLAa domains, as well as in the posterior BLA, ventral BLA, posterior basomedial, and lateral amygdalar nuclei. Inputs to each nucleus also are identified via retrograde tracing. The data suggests that connectionally unique, domain-specific BLAa neurons are associated with distinct behavior networks.
Indexed as
Action PotentialsAlgorithmsAnimalsBasolateral Nuclear ComplexFearFemaleMaleMiceMice, Inbred C57BLModels, NeurologicalNerve NetNeuronsOptogenetics
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