Evidence map›Paper›PMID 34001853›Full record

ArticleBlood cancer journal2021

SIRT3 overexpression and epigenetic silencing of catalase regulate ROS accumulation in CLL cells activating AXL signaling axis.

Guru P Maiti, Sutapa Sinha, Hasan Mahmud, Justin Boysen, Mariana T Mendez, Sara K Vesely, Jennifer Holter-Chakrabarty, Neil E Kay, Asish K Ghosh

Open access · goldAbstract read
In one paragraph

Article in Blood cancer journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Keratinocytes: pleiotropic orchestrators of cutaneous immunity and Inflammation - Emerging therapeutic paradigms in dermatological pathologies.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
    Review
  3. Article
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  6. Aberrantly Expressed Mitochondrial Lipid Kinase, AGK, Activates JAK2-Histone H3 Axis and BCR Signal: A Mechanistic Study with Implication in CLL Therapy.Clinical cancer research : an official journal of the American Association for Cancer Research · 2025
    Article
  7. Roles of SIRT3 in aging and aging-related diseases.International journal of biological sciences · 2025
    Review
  8. Review
  9. Targeting catalase in cancer.Redox biology · 2024
    Review
  10. Review
  11. Review
  12. Review
  13. Article
  14. Review
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Guru P Maiti *Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA.ORCID 0000-0003-1936-363X
Sutapa Sinha *Division of Hematology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.
Hasan Mahmud *Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA.
Justin BoysenDivision of Hematology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.
Mariana T MendezDepartment of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA.
Sara K VeselyStephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA.
Jennifer Holter-ChakrabartyStephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA.
Neil E KayDivision of Hematology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.ORCID 0000-0002-5951-5055
Asish K GhoshStephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA. asish-ghosh@ouhsc.edu.ORCID 0000-0002-4885-094X
University of Oklahoma Health Sciences Center · USMayo Clinic · US

Funding

Tissue Pathology Shared ResourceP30CA225520 · NCI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI Michael S. Businelle · 2018 to 2026
$27.1M
Microvesicle Dynamics in B-Cell Chronic Lymphocytic Leukemia Tumor MicroenvironmeR01CA170006 · NCI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI GHOSH, ASISH KUMAR · 2013 to 2017
$1.6M
NCI NIH HHS P30 CA225520NCI NIH HHS R01 CA170006
6 · The paper itself

Abstract

Mitochondrial metabolism is the key source for abundant ROS in chronic lymphocytic leukemia (CLL) cells. Here, we detected significantly lower superoxide anion (O

Indexed as

Signal TransductionAdultAgedAged, 80 and overAxl Receptor Tyrosine KinaseCatalaseFemaleGene Expression Regulation, LeukemicGene SilencingHumansLeukemia, Lymphocytic, Chronic, B-CellMaleMiddle AgedProto-Oncogene ProteinsReactive Oxygen SpeciesReceptor Protein-Tyrosine KinasesAXL protein, humanAxl Receptor Tyrosine KinaseCatalaseCAT protein, humanProto-Oncogene ProteinsReactive Oxygen SpeciesReceptor Protein-Tyrosine KinasesSIRT3 protein, humanSirtuin 3

Identifiers

PMID34001853
PMCPMC8129117
OpenAlexW3161930878

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.