Evidence map›Paper›PMID 34001684›Full record

ArticleThe Kobe journal of medical sciences2021

HbA1c levels Measured by Enzymatic Assay and Immunoassay during Off-Site Health Checkups Are Both Lower than Those Measured by On-Site HPLC Assay.

Kayoko Goya, Sayaka Tanaka, Toki Makio, Mayu Kanno, Yukiko Tabuchi, Keisuke Fukuzawa, Kazuhiro Nonoguchi, Midori Ishibashi, Masafumi Koga

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in The Kobe journal of medical sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Kayoko GoyaDepartment of Internal Medicine, Nishinomiya Municipal Central Hospital, Nishinomiya, Japan.
Sayaka TanakaDepartment of Internal Medicine, Nishinomiya Municipal Central Hospital, Nishinomiya, Japan.
Toki MakioDepartment of Internal Medicine, Nishinomiya Municipal Central Hospital, Nishinomiya, Japan.
Mayu KannoDepartment of Internal Medicine, Nishinomiya Municipal Central Hospital, Nishinomiya, Japan.
Yukiko TabuchiDepartment of Internal Medicine, Nishinomiya Municipal Central Hospital, Nishinomiya, Japan.
Keisuke FukuzawaDepartment of Clinical Diagnostic Laboratory Medicine, Nishinomiya Municipal Central Hospital, Nishinomiya, Japan.
Kazuhiro NonoguchiDepartment of Clinical Diagnostic Laboratory Medicine, Nishinomiya Municipal Central Hospital, Nishinomiya, Japan.
Midori IshibashiDepartment of Clinical Laboratory Medicine, New Tokyo Hospital, Matsudo, Japan.
Masafumi KogaDepartment of Internal Medicine, Hakuhokai Central Hospital, Amagasaki, Japan.
Nishinomiya Municipal Central Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It has already been reported that HbA1c levels measured by immunoassay (IA) (IA-HbA1c) during off-site health checkups present falsely lower results. We also reported that HbA1c levels measured by enzymatic assay (EA) (EA-HbA1c) during off-site health checkups are lower. In the present study, we compared IA-HbA1c levels or EA-HbA1c levels during off-site health checkups with on-site high-performance liquid chromatography (HPLC)-HbA1c levels using the same samples. Subjects were 88 non-diabetic individuals who had health checkups in Nishinomiya Municipal Central Hospital. Subjects with a history of diabetes mellitus and those with HPLC-HbA1c ≥ 6.5% were excluded. IA-HbA1c levels (Study 1) or EA-HbA1c levels (Study 2) in the health checkups were compared with on-site HPLC-HbA1c levels using the same samples. Both IA-HbA1c levels and EA-HbA1c levels had positive correlations with HPLC-HbA1c levels (p <0.0001 for both), although both were significantly lower than HPLC-HbA1c levels (p <0.0001 for both). The degrees of reductions in the IA-HbA1c levels and EA-HbA1c levels compared with HPLC-HbA1c levels were almost same to each other. Similarly to IA-HbA1c levels, EA-HbA1c levels during the health checkups were lower than HPLC-HbA1c levels. It was demonstrated that HbA1c levels decrease similarly if measured by either EA or IA during off-site health checkups.

Indexed as

AgedAged, 80 and overChromatography, High Pressure LiquidEnzyme AssaysFemaleGlycated HemoglobinHumansImmunoassayMaleMiddle AgedSensitivity and SpecificityGlycated HemoglobinEnzymatic assayHbA1cHealth checkupHPLCImmunoassay

Identifiers

PMID34001684
PMCPMC8212803
OpenAlexW3160093785

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.