ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2021
Elimination of the Cortico-Subthalamic Hyperdirect Pathway Induces Motor Hyperactivity in Mice.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 27 citations in OpenAlex.
- Article
- Motor cortex directly excites the substantia nigra pars reticulata, the basal ganglia output nucleus.Nature communications · 2026Article
- A chromosome region linked to neurodevelopmental disorders influences locomotor behavior through sex-specific neural circuits.Nature communications · 2026Article
- Treadmill exercise improves motor deficits and partially normalizes electrophysiological properties of substantia nigra pars reticulata PV-lineage neurons in 6-OHDA-lesioned mice.Frontiers in physiology · 2026Article
- Synaptic integration and competition in the substantia nigra pars reticulata-An experimental and in silico analysis.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Altered Cortical Gyrification, Functional Connections, and Underlying Neurotransmitter Information in Patients with Parkinson's Disease with Levodopa-Induced Dyskinesia.Neurology and therapy · 2025Article
- Embodied sensorimotor control: computational modeling of the neural control of movement.ArXiv · 2025Article
- Similar Dynamic Frontal Cortex Representations of Auditory Stimuli Cueing Opposite Actions and Rewards.bioRxiv : the preprint server for biology · 2025Article
- Anterior Cingulate Cortex Contributes to the Hyperlocomotion under Nitrogen Narcosis.Neuroscience bulletin · 2025Article
- Whether or not to act is determined by distinct signals from motor thalamus and orbitofrontal cortex to secondary motor cortex.Nature communications · 2025Article
- Autistic behavior is a common outcome of biallelic disruption of PDZD8 in humans and mice.Molecular autism · 2025Article
- Subthalamic Activity for Motor Execution and Cancelation in Monkeys.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Adaptation of sequential action benefits from timing variability related to lateral basal ganglia circuitry.iScience · 2024Article
- The cortico-striatal circuitry in autism-spectrum disorders: a balancing act.Frontiers in cellular neuroscience · 2023Review
- Motor cortico-nigral and cortico-entopeduncular information transmission and its modulation by buspirone in control and after dopaminergic denervation.Frontiers in pharmacology · 2022Article
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
The substantia nigra pars reticulata (SNr) is the output station of the basal ganglia and receives cortical inputs by way of the following three basal ganglia pathways: the cortico-subthalamo (STN)-SNr hyperdirect, the cortico-striato-SNr direct, and the cortico-striato-external pallido-STN-SNr indirect pathways. Compared with the classical direct and indirect pathways via the striatum, the functions of the hyperdirect pathway remain to be fully elucidated. Here we used a photodynamic technique to selectively eliminate the cortico-STN projection in male mice and observed neuronal activity and motor behaviors in awake conditions. After cortico-STN elimination, cortically evoked early excitation in the SNr was diminished, while the cortically evoked inhibition and late excitation, which are delivered through the direct and indirect pathways, respectively, were unchanged. In addition, locomotor activity was significantly increased after bilateral cortico-STN elimination, and apomorphine-induced ipsilateral rotations were observed after unilateral cortico-STN elimination, suggesting that cortical activity was increased. These results are compatible with the notion that the cortico-STN-SNr hyperdirect pathway quickly conveys cortical excitation to the output station of the basal ganglia, resets or suppresses the cortical activity related to ongoing movements, and prepares for the forthcoming movement.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.