Evidence map›Paper›PMID 34001624›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Circulating immunity protects the female reproductive tract from

Jasmine C Labuda, Oanh H Pham, Claire E Depew, Kevin D Fong, Bokyung S Lee, Jordan A Rixon, Stephen J McSorley

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Protective Immunity againstInternational journal of molecular sciences · 2023
    Article
  12. Female reproductive tract-organ axes.Frontiers in immunology · 2023
    Review
  13. Review
  14. Article
  15. Review
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jasmine C LabudaCenter for Immunology and Infectious Diseases, Department of Anatomy, Physiology, and Cell Biology, School of Veterinary Medicine, University of California, Davis, CA 95616.ORCID 0000-0001-6078-5733
Oanh H PhamCenter for Immunology and Infectious Diseases, Department of Anatomy, Physiology, and Cell Biology, School of Veterinary Medicine, University of California, Davis, CA 95616.
Claire E DepewCenter for Immunology and Infectious Diseases, Department of Anatomy, Physiology, and Cell Biology, School of Veterinary Medicine, University of California, Davis, CA 95616.
Kevin D FongCenter for Immunology and Infectious Diseases, Department of Anatomy, Physiology, and Cell Biology, School of Veterinary Medicine, University of California, Davis, CA 95616.ORCID 0000-0002-8573-0576
Bokyung S LeeCenter for Immunology and Infectious Diseases, Department of Anatomy, Physiology, and Cell Biology, School of Veterinary Medicine, University of California, Davis, CA 95616.
Jordan A RixonCenter for Immunology and Infectious Diseases, Department of Anatomy, Physiology, and Cell Biology, School of Veterinary Medicine, University of California, Davis, CA 95616.ORCID 0000-0002-8313-0702
Stephen J McSorleyCenter for Immunology and Infectious Diseases, Department of Anatomy, Physiology, and Cell Biology, School of Veterinary Medicine, University of California, Davis, CA 95616 sjmcsorley@ucdavis.edu.ORCID 0000-0002-6363-3222

Funding

Animal Models of Infectious Diseases Training ProgramT32AI060555 · NIAID · UNIVERSITY OF CALIFORNIA DAVIS · PI MCSORLEY, STEPHEN J · 2004 to 2025
$3.3M
Target antigen identification to improve Salmonella vaccinationR01AI139410 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI STEPHEN J MCSORLEY, Renee M Tsolis · 2018 to 2026
$2.9M
Salmonella-specific Th1 cell function and residenceR01AI139047 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI MCSORLEY, STEPHEN J · 2019 to 2023
$1.9M
CD4 T cell responses to Chlamydia infectionR01AI103422 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI MCSORLEY, STEPHEN J · 2016 to 2019
$1.5M
Improving Food Allergy Management through an Electronic Physician Support ToolR21AI103433 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GUPTA, RUCHI S · 2013 to 2014
$415k
NIAID NIH HHS R01 AI103422NIAID NIH HHS R01 AI139047NIAID NIH HHS R01 AI139410NIAID NIH HHS R21 AI103433NIAID NIH HHS T32 AI060555
6 · The paper itself

Abstract

Anatomical positioning of memory lymphocytes within barrier tissues accelerates secondary immune responses and is thought to be essential for protection at mucosal surfaces. However, it remains unclear whether resident memory in the female reproductive tract (FRT) is required for Chlamydial immunity. Here, we describe efficient generation of tissue-resident memory CD4 T cells and memory lymphocyte clusters within the FRT after vaginal infection with

Indexed as

Administration, IntranasalAdministration, IntravaginalAnimalsAntibodies, BacterialAntigens, BacterialBacterial VaccinesCD4-Positive T-LymphocytesCell MovementChlamydia InfectionsChlamydia muridarumFemaleGenitalia, FemaleImmunity, MucosalImmunizationImmunologic MemoryMiceAntibodies, BacterialAntigens, BacterialBacterial VaccinesCD4 T cellsChlamydiafemale reproductive tract

Identifiers

PMID34001624
PMCPMC8166081

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.