Evidence map›Paper›PMID 34001582›Full record

ArticleClinical medicine (London, England)2021

Aerosolised fluorescein can quantify FFP mask faceseal leakage: a cost-effective adaptation to the existing point of care fit test.

Sameer Zaman, Henry Seligman, Freya Hepworth Lloyd, Keval T Patel, Digby Chappell, Danny O'Hare, Graham D Cole, Darrel P Francis, Ricardo Petraco, Nick Wf Linton

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical medicine (London, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. New wine in old skins.Clinical medicine (London, England) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Sameer ZamanImperial College London, London, UK.
Henry SeligmanImperial College London, London, UK.
Freya Hepworth LloydImperial College London, London, UK.
Keval T PatelGuy's and St Thomas' NHS Foundation Trust, London, UK.
Digby ChappellImperial College London, London, UK.
Danny O'HareImperial College London, London, UK.
Graham D ColeImperial College Healthcare NHS Trust, London, UK.
Darrel P FrancisImperial College London, London, UK and Imperial College Healthcare NHS Trust, London, UK.
Ricardo PetracoImperial College London, London, UK and Imperial College Healthcare NHS Trust, London, UK.
Nick Wf LintonImperial College London, London, UK and Imperial College Healthcare NHS Trust, London, UK nick.linton@imperial.ac.uk.
Imperial College London · GBThe London College · GBGuy's and St Thomas' NHS Foundation Trust · GBImperial College Healthcare NHS Trust · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundA qualitative fit test using bitter-tasting aerosols is the commonest way to determine filtering face-piece (FFP) mask leakage. This taste test is subjective and biased by placebo. We propose a cheap, quantitative modification of the taste test by measuring the amount of fluorescein stained filter paper behind the mask using image analysis.

methodsA bitter-tasting fluorescein solution was aerosolised during mask fit tests, with filter paper placed on masks' inner surfaces. Participants reported whether they could taste bitterness to determine taste test 'pass' or 'fail' results. Filter paper photographs were digitally analysed to quantify total fluorescence (TF).

resultsFifty-six healthcare professionals were fit tested; 32 (57%) 'passed' the taste test. TF between the taste test 'pass' and 'fail' groups was significantly different (p<0.001). A cut-off (TF = 5.0 × 10

conclusionFluorescein is detectable and sensitive at identifying FFP mask leaks. These low-cost adaptations can enhance exiting fit testing to determine 'pass' and 'fail' groups, protecting those who 'passed' the taste test but have high fluorescein leak, and reassuring those who 'failed' the taste test despite having little fluorescein leak.

Indexed as

Occupational ExposureRespiratory Protective DevicesCost-Benefit AnalysisFluoresceinHumansPoint-of-Care SystemsFluoresceinFFPfiltering masksfluoresceininfection controlPPE

Identifiers

PMID34001582
PMCPMC8140700
OpenAlexW3110985250

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.