Evidence map›Paper›PMID 34001525›Full record

ReviewCold Spring Harbor perspectives in medicine2021

Early Diagnosis and Screening for Lung Cancer.

Humam Kadara, Linh M Tran, Bin Liu, Anil Vachani, Shuo Li, Ansam Sinjab, Xianghong J Zhou, Steven M Dubinett, Kostyantyn Krysan

Abstract readReview
In one paragraph

Review in Cold Spring Harbor perspectives in medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Humam KadaraDepartment of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Linh M TranDepartment of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA.
Bin LiuDepartment of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA.
Anil VachaniPulmonary, Allergy, and Critical Care Division, Department of Medicine, University of Pennsylvania and Philadelphia VA Medical Center, Philadelphia, Pennsylvania 19104, USA.
Shuo LiDepartment of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA.
Ansam SinjabDepartment of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Xianghong J ZhouDepartment of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA.
Steven M DubinettDepartment of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA.
Kostyantyn KrysanDepartment of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA.ORCID 0000-0003-0250-1346

Funding

The UCLA Center in Early Detection of Liver CancerU01CA230705 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Vatche Agopian, Samuel Wheeler French · 2018 to 2026
$6.6M
Novel Computation Methods for the Analysis of Cell-Free DNA Sequence DataR01CA246329 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M., LI, WENYUAN · 2019 to 2022
$2.2M
Informatics resources for liquid biopsy researchU01CA237711 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LI, WENYUAN · 2019 to 2021
$1.1M
NCI NIH HHS R01 CA246329NCI NIH HHS U01 CA230705NCI NIH HHS U01 CA237711
6 · The paper itself

Abstract

Cancer interception refers to actively blocking the cancer development process by preventing progression of premalignancy to invasive disease. The rate-limiting steps for effective lung cancer interception are the incomplete understanding of the earliest molecular events associated with lung carcinogenesis, the lack of preclinical models of pulmonary premalignancy, and the challenge of developing highly sensitive and specific methods for early detection. Recent advances in cancer interception are facilitated by developments in next-generation sequencing, computational methodologies, as well as the renewed emphasis in precision medicine and immuno-oncology. This review summarizes the current state of knowledge in the areas of molecular abnormalities in lung cancer continuum, preclinical human models of lung cancer pathogenesis, and the advances in early lung cancer diagnostics.

Indexed as

Early Detection of CancerMass ScreeningBiomarkers, TumorDNA MethylationHumansLung NeoplasmsNeoplastic Cells, CirculatingPrecision MedicineProteomicsRisk AssessmentBiomarkers, Tumor

Identifiers

PMID34001525
PMCPMC8415293

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.