Evidence map›Paper›PMID 34001269›Full record

ArticleCell & bioscience2021

Bone marrow mesenchymal stem cells promote prostate cancer cell stemness via cell-cell contact to activate the Jagged1/Notch1 pathway.

Ji-Wen Cheng, Li-Xia Duan, Yang Yu, Pu Wang, Jia-le Feng, Guan-Zheng Feng, Yan Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell & bioscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Review
  9. Review
  10. Prostate Cancer Stem Cells: Biology and Treatment Implications.International journal of molecular sciences · 2023
    Review
  11. Hypoxia promotes conversion to a stem cell phenotype in prostate cancer cells by activating HIF-1α/Notch1 signaling pathway.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2023
    Article
  12. Review
  13. Review
  14. Review
  15. Extracellular Vesicles (EVs) in Tumor Diagnosis and Therapy.Technology in cancer research & treatment
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ji-Wen Cheng *Department of Urology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Li-Xia Duan *Department of Urology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Yang Yu *Department of Urology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
Pu WangDepartment of Urology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Jia-le FengDepartment of Urology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Guan-Zheng FengDepartment of Urology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Yan LiuDepartment of Orthopedics, The First Affiliated Hospital of Guangxi Medical University, Nanning, China. liuyansunny@163.com.ORCID http://orcid.org/0000-0003-1331-6920

Funding

China Postdoctoral Science Foundation 2017M623295XBNational Natural Science Foundation of China 81602315National Natural Science Foundation of China 81660424National Natural Science Foundation of China 81760478National Natural Science Foundation of China 81960477National Natural Science Foundation of Guangxi 2018GXNSFAA138207The Guangxi Natural Science Foundation 2018GXNSFAA138027
6 · The paper itself

Abstract

backgroundMesenchymal stem cells (MSCs) play a crucial role in cancer development and tumor resistance to therapy in prostate cancer, but the influence of MSCs on the stemness potential of PCa cells by cell-cell contact remains unclear. In this study, we investigated the effect of direct contact of PCa cells with MSCs on the stemness of PCa and its mechanisms.

methodsFirst, the flow cytometry, colony formation, and sphere formation were performed to determine the stemness of PCa

resultsWe established that MSCs promoted the stemness of PCa cells by cell-cell contact. We here established that the enhanced stemness of PCa

conclusionsOur results reveal a novel interaction between MSCs and PCa cells in promoting tumorigenesis through activation of the Jagged1/Notch1 pathway, providing a new therapeutic target for the treatment of PCa.

Indexed as

Cell–cell contactMSCsNotch pathwayProstate cancerStemness

Identifiers

PMID34001269
PMCPMC8130143

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.