ArticleCell & bioscience2021
Synonymous point mutation of gtfB gene caused by therapeutic X-rays exposure reduced the biofilm formation and cariogenic abilities of Streptococcus mutans.
Article in Cell & bioscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 20 citations in OpenAlex.
- Geraniol attenuates Streptococcus mutans biofilm and virulence as an anti-caries agent.Archives of microbiology · 2026Article
- Energy-assisted CRISPR cleavage and probiotic vesicle signaling platform: Microbiome reprogramming for homeostasis.Science advances · 2026Article
- Bacterial extracellular vesicles from Streptococcus mutans drive OSCC progression through β-catenin signaling.Scientific reports · 2026Article
- Capsaicin inhibits cariogenicJournal of oral microbiology · 2026Article
- Artemisinins inhibited the synergistic cariogenic effect betweenFrontiers in cellular and infection microbiology · 2026Article
- Evaluating microbial regulation as a preventive strategy for radiation-related caries: A review.Head & face medicine · 2025Review
- Sugar Substitute Stevia Inhibits Biofilm Formation, Exopolysaccharide Production, and Downregulates the Expression of Streptococcal Genes Involved in Exopolysaccharide Synthesis.Dentistry journal · 2023Article
- Heavy Ion Radiation Directly Induced the Shift of Oral Microbiota and Increased the Cariogenicity ofMicrobiology spectrum · 2023Article
- Article
- Extracellular vesicles of Candida albicans regulate its own growth through the L-arginine/nitric oxide pathway.Applied microbiology and biotechnology · 2023Article
- Candida albicans CHK1 gene regulates its cross-kingdom interactions with Streptococcus mutans to promote caries.Applied microbiology and biotechnology · 2022Article
- Effects of a Novel, Intelligent, pH-Responsive Resin Adhesive on Cariogenic Biofilms In Vitro.Pathogens (Basel, Switzerland) · 2022Article
- The FnBPA from methicillin-resistantJournal of oral microbiology · 2022Article
- Over 300 Radiation Caries Papers: Reflections From the Rearview Mirror.Frontiers in oral health · 2022Review
- Natural products from traditional medicine as promising agents targeting at different stages of oral biofilm development.Frontiers in microbiology · 2022Review
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundThe shift of oral microbiota is a critical factor of radiation caries in head and neck cancer patients after the radiotherapy. However, the direct effects of irradiation on the genome and virulence of cariogenic bacteria are poorly described. Here we investigated the genomic mutations and virulence change of Streptococcus mutans (S. mutans), the major cariogenic bacteria, exposed to the therapeutic doses of X-rays.
resultsX-ray reduced the survival fraction of S. mutans and impacted its biofilm formation. We isolated a biofilm formation-deficient mutant #858 whose genome only possessed three synonymous mutations (c.2043 T > C, c.2100C > T, c.2109A > G) in gtfB gene. The "silent mutation" of c.2043 T > C in gtfB gene can cause the down-regulation of all of the gtfs genes' expression and decrease the GtfB enzyme secretion without the effect on the growth due to the codon bias. #858 and synonymous point mutation strain gtfB
conclusionThe direct exposure of X-ray radiation can affect the genome and virulence of oral bacteria even at therapeutic doses. The synonymous mutations of genome are negligent factors for gene expression and related protein translation due to the codon usage frequency.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.