Evidence map›Paper›PMID 34001168›Full record

Trial reportJournal of the International Society of Sports Nutrition2021

The effect of probiotic supplementation on performance, inflammatory markers and gastro-intestinal symptoms in elite road cyclists.

Chen Schreiber, Snait Tamir, Ron Golan, Ayelet Weinstein, Yitzhak Weinstein

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of the International Society of Sports Nutrition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02756221 (The Effect of Probiotic Supplementation on the Incidence of Gastrointestinal), which is not on this map. Cited by 36 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 14 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02756221 nacompletednot on this map

The Effect of Probiotic Supplementation on the Incidence of Gastrointestinal (GI) Tract and Upper Respiratory System Symptoms and the Endurance Exercise Performance in Masters Runners and Elite Cyclists

TypeinterventionalSponsorTel Hai CollegeRan2016 to 2018Enrolled42ConditionsViral Upper Respiratory Tract Infection, GastroenteritisArmsProbiotics, Placebo
3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 14 syntheses or guidelines pooled it, 49 citations in OpenAlex.

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  10. Effects of Probiotics Supplementation on Risk and Severity of Infections in Athletes: A Systematic Review.International journal of environmental research and public health · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Chen SchreiberDepartment of Nutritional Sciences, Faculty of Science and Technology, Tel Hai Academic College , 1220800, Tel Hai, Israel.
Snait TamirDepartment of Nutritional Sciences, Faculty of Science and Technology, Tel Hai Academic College , 1220800, Tel Hai, Israel.
Ron GolanZiv Medical Center, Zefat, Israel.
Ayelet WeinsteinDepartment of Nutritional Sciences, Faculty of Science and Technology, Tel Hai Academic College , 1220800, Tel Hai, Israel.
Yitzhak WeinsteinDepartment of Nutritional Sciences, Faculty of Science and Technology, Tel Hai Academic College , 1220800, Tel Hai, Israel. itzw@wincol.ac.il.
Tel Hai Academic College · ILZefat Academic College · IL

Funding

Altman Health Research Institute, Israel Altman Health Research Institute, IsraelTel Hai Academic College Research fund Tel Hai Academic College Research fund
6 · The paper itself

Abstract

backgroundElite athletes may suffer from impaired immune function and gastro-intestinal (GI) symptoms, which may affect their health and may impede their performance. These symptoms may be reduced by multi-strain probiotic supplementation. Therefore, the aim of the current study is to examine the effects of probiotic supplementation on aerobic fitness characteristics, inflammatory markers and incidence and severity of GI symptoms in elite cyclists.

methodsTwenty-seven male cyclists, ranked elite or category 1 level competitions, were randomly assigned to a multi-strain probiotic-supplemented group (E, n = 11) or placebo group (C, n = 16). All participants visited the laboratory at the beginning of the study and following 90 d of supplementation/placebo. Prior to testing, all participants completed a GI symptoms questionnaire and underwent physical and medical examination, and anthropometric measurements. Venous blood was drawn for inflammatory markers analysis. The cyclists then underwent maximal oxygen consumption (VO

resultsLower incidence of nausea, belching, and vomiting (P < 0.05) at rest, and decreased incidence of GI symptoms during training were found in E group vs. C Group, respectively (∆GI -0.27 ± 0.47 % vs. 0.08 ± 0.29 %, P = 0.03), no significant changes were observed in the incidence of total overall GI symptoms (∆GI -5.6 ± 14.7 % vs. 2.6 ± 11.6 %, P = 0.602) Mean rate of perceived exertion (RPE) values during the TTF were lower in E group (∆RPE: -0.3 ± 0.9 vs. 0.8 ± 1.5, P = 0.04). No significant changes were measured between and within groups in VO

conclusionsProbiotics supplementation may have beneficial effects on GI symptoms in elite cyclists. Future studies, using higher doses and during different training seasons, might help understanding the effects of probiotic supplementation on elite athletes' health and performance.

trial registrationNIH clinicaltrial.gov #NCT02756221 Registered 25 April 2016.

Indexed as

Dietary SupplementsAdultAthletic PerformanceBicyclingBiomarkersC-Reactive ProteinDouble-Blind MethodGastrointestinal DiseasesHumansInflammationInterleukin-6MaleMuscle FatigueOxygen ConsumptionPhysical Conditioning, HumanProbioticsBiomarkersC-Reactive ProteinIL6 protein, humanInterleukin-6Tumor Necrosis Factor-alphaCycling performanceCyclistsGastrointestinal integrityGastrointestinal symptomsProbioticsProbiotic supplementation

Identifiers

PMID34001168
PMCPMC8127283
OpenAlexW3163734009

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.