Evidence map›Paper›PMID 34001157›Full record

ArticleJournal of nanobiotechnology2021

Multifunctional nanoplatforms as cascade-responsive drug-delivery carriers for effective synergistic chemo-photodynamic cancer treatment.

Fan Li, Yan Liang, Miaochen Wang, Xing Xu, Fen Zhao, Xu Wang, Yong Sun, Wantao Chen

Abstract read
In one paragraph

Article in Journal of nanobiotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Nanomedicine in cancer therapy.Signal transduction and targeted therapy · 2023
    Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Fan LiDepartment of Oral and Maxillofacial Head & Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.
Yan LiangDepartment of Pharmaceutics, Qingdao University School of Pharmacy, Qingdao, 266021, China.
Miaochen WangDepartment of Oral and Maxillofacial Head & Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.
Xing XuDepartment of Oral and Maxillofacial Head & Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.
Fen ZhaoShanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, National Clinical Research Center of Stomatology, Shanghai, 200011, China.
Xu WangDepartment of Oral and Maxillofacial Head & Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China. wangx312016@sh9hospital.org.cn.
Yong SunDepartment of Pharmaceutics, Qingdao University School of Pharmacy, Qingdao, 266021, China. sunyong@qdu.edu.cn.
Wantao ChenDepartment of Oral and Maxillofacial Head & Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China. chenwantao196323@sjtu.edu.cn.ORCID http://orcid.org/0000-0002-9307-162X

Funding

Shanghai Municipal Science and Technology Commission Funded Project 16431903300 and 18DZ2291500the National Program on Key Research Project of China 2016YFC0902700
6 · The paper itself

Abstract

Synergistic chemo-photodynamic therapy has garnered attention in the field of cancer treatment. Here, a pH cascade-responsive micellar nanoplatform with nucleus-targeted ability, for effective synergistic chemo-photodynamic cancer treatment, was fabricated. In this micellar nanoplatform, 5-(4-carboxyphenyl)-10,15,20-triphenylporphyrin (Por), a photodynamic therapy (PDT) agent was utilized for carrying the novel anticancer drug GNA002 to construct a hydrophobic core, and cyclic RGD peptide (cRGD)-modified polyethylene glycol (PEG) (cRGD-PEG) connected the cell-penetrating peptide hexaarginine (R

Indexed as

AnimalsAntineoplastic AgentsCell Line, TumorDrug CarriersDrug Delivery SystemsFemaleHumansLysosomesMaleMiceMice, Inbred BALB CMice, NudeNanoparticlesNeoplasmsPeptides, CyclicPhotochemotherapyAntineoplastic Agentscyclic arginine-glycine-aspartic acid peptideDrug CarriersPeptides, CyclicPhotosensitizing AgentsPolyethylene GlycolsReactive Oxygen SpeciesDrug deliveryMultifunctional nanoplatformNuclear targetingPH-responsive amphiphilic polymerSynergistic anticancer therapy

Identifiers

PMID34001157
PMCPMC8130269

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.