ArticleBMC ophthalmology2021
Early neurovascular changes in the retina in preclinical diabetic retinopathy and its relation with blood glucose.
Article in BMC ophthalmology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.
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Who cites it
10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 18 citations in OpenAlex.
- Optical coherence tomography angiography analysis methods: a systematic review and meta-analysis.Scientific reports · 2024Pooled it
- Retina and microvascular alterations in migraine: a systemic review and meta-analysis.Frontiers in neurology · 2023Pooled it
- Association of Retinal Microvasculature With Myopia Progression in Children: The Hong Kong Children Eye Study.Investigative ophthalmology & visual science · 2025Article
- The Correlation Between Macular Vessel Density and Its Clinical Parameters in Diabetes Mellitus Type 2.Clinical ophthalmology (Auckland, N.Z.) · 2025Article
- Autoencoder-based phenotyping of ophthalmic images highlights genetic loci influencing retinal morphology and provides informative biomarkers.Bioinformatics (Oxford, England) · 2024Article
- Microstructural Changes in the Macula Following Cataract Surgery in Patients with Type 2 Diabetes Mellitus Detected Using Optical Coherence Tomography Angiography.Diagnostics (Basel, Switzerland) · 2023Article
- Early changes to retinal structure in patients with diabetic retinopathy as determined by ultrawide swept-source optical coherence tomography-angiography.Frontiers in endocrinology · 2023Observational
- Early retinal functional alteration in relation to diabetes duration in patients with type 2 diabetes without diabetic retinopathy.Scientific reports · 2022Article
- Optical coherence tomography angiography metrics in different stages of diabetic macular edema.Eye and vision (London, England) · 2022Article
- Multiple Single Nucleotide Polymorphism Testing Improves the Prediction of Diabetic Retinopathy Risk with Type 2 Diabetes Mellitus.Journal of personalized medicine · 2021Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo investigate the changes in retinal nerve fiber layer thickness and macular blood flow density during the preclinical stage of diabetic retinopathy and their relationship with blood glucose.
methodsIn this cross-sectional study, 97 diabetic patients (total of 188 eyes; 144 eyes in no diabetic retinopathy group, 44 eyes in mild diabetic non-proliferative retinopathy group) and 35 healthy people (70 eyes) were enrolled, All the subjects were divided into different groups based on their HbA1c levels, and they underwent optical coherence tomography angiography. We compared the optical coherence tomography angiography parameters and retinal nerve fiber layer thickness among the different glucose groups.
resultsThe parafoveal vessel density and the temporal retinal nerve fiber layer thickness were lower (p < 0.05) in the diabetic group than in the normal group. The diabetic group showed a higher acircularity index than the normal group. The normal group had the highest vessel density and the lowest acircularity index, followed by the no-diabetic retinopathy group and the mild non-proliferative retinopathy group, (p < 0.001). Foveal vascular density and parafoveal vessel density decreased with an increase in HbA1c. There was a negative correlation between parafoveal vessel density in the deep retinal vascular layer and fasting blood glucose (p < 0.01). The temporal retinal nerve fiber layer thickness decreased across the HbA1c level groups, and was positively correlated with the parafoveal vessel density in the superficial retinal vascular layer (p < 0.05).
conclusionsThis study shows that retinal microvasculopathy and neuropathy can be present in the absence of retinopathy. The vessel density of the deep retinal vascular layer was negatively correlated with fasting blood glucose, and the temporal retinal nerve fiber layer thickness was positively correlated with the vessel density of the superficial retinal vascular layer. These indicators are helpful for endocrinologists and ophthalmologists in detecting early diabetic retinal pathological lesions.
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