Evidence map›Paper›PMID 34000759›Full record

ArticlePharmacology research & perspectives2021

Chemogenetic activation of central gastrin-releasing peptide-expressing neurons elicits itch-related scratching behavior in male and female mice.

Norikazu Kiguchi, Yohji Fukazawa, Ayano Saika, Daisuke Uta, Fumihiro Saika, Tomoe Y Nakamura, Mei-Chuan Ko, Shiroh Kishioka

Open access · goldAbstract read
In one paragraph

Article in Pharmacology research & perspectives, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Spinal neuropeptide Y Y1 receptor-expressing neurons are a pharmacotherapeutic target for the alleviation of neuropathic pain.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Norikazu KiguchiDepartment of Pharmacology, Wakayama Medical University, Wakayama City, Wakayama, Japan.ORCID 0000-0001-5401-8650
Yohji FukazawaDepartment of Anatomy, Kansai University of Health Sciences, Sennan-gun, Osaka, Japan.
Ayano SaikaDepartment of Pharmacology, Wakayama Medical University, Wakayama City, Wakayama, Japan.
Daisuke UtaDepartment of Applied Pharmacology, Faculty of Pharmaceutical Sciences, University of Toyama, Toyama City, Toyama, Japan.
Fumihiro SaikaDepartment of Pharmacology, Wakayama Medical University, Wakayama City, Wakayama, Japan.
Tomoe Y NakamuraDepartment of Pharmacology, Wakayama Medical University, Wakayama City, Wakayama, Japan.
Mei-Chuan KoDepartment of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Shiroh KishiokaFaculty of Wakayama Health Care Sciences, Takarazuka University of Medical and Health Care, Wakayama City, Wakayama, Japan.
Wakayama Medical University · JPOsaka University of Health and Sport Sciences · JPUniversity of Toyama · JPWake Forest University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Several lines of evidence have clarified that the key transmission pathways of itching sensation travel from the periphery to the central nervous system (CNS). Despite the functional significance of gastrin-releasing peptide (GRP) and its cognate receptor in the itch processing mechanism in the spinal dorsal horn (SDH), the roles of GRP-expressing (GRP

Indexed as

AnimalsBehavior, AnimalClozapineCyclopropanesDermatitis, ContactFemaleGastrin-Releasing PeptideHaptensMaleMiceMice, Inbred C57BLMice, TransgenicNeuronsPruritusClozapineclozapine N-oxideCyclopropanesdiphenylcyclopropenoneGastrin-Releasing PeptideHaptensdorsal hornDREADDGRPGRPRpruritussexspinal cord

Identifiers

PMID34000759
PMCPMC8128314
OpenAlexW3161184956

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.