Evidence map›Paper›PMID 34000480›Full record

ReviewSexual medicine2021

Restorative Therapies for Erectile Dysfunction: Position Statement From the Sexual Medicine Society of North America (SMSNA).

James L Liu, Kevin Y Chu, Andrew T Gabrielson, Run Wang, Landon Trost, Gregory Broderick, Kelvin Davies, Gerald Brock, John Mulhall, Ranjith Ramasamy and 1 more

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Sexual medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 2 pooled it
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 50 citations in OpenAlex.

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  9. An overview of the Canadian landscape on the use of restorative therapies for erectile dysfunction and Peyronie's disease.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 8 institutions in 2 countries.

James L LiuThe James Buchanan Brady Urological Institute and Department of Urology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Kevin Y ChuDepartment of Urology, Miller School of Medicine, University of Miami, Miami, FL, USA.
Andrew T GabrielsonThe James Buchanan Brady Urological Institute and Department of Urology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Run WangDivision of Urology, The University of Texas McGovern Medical School and Department of Urology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Landon TrostDepartment of Urology, Mayo Clinic, Rochester, MN, USA; Brigham Young University, Provo, UT, USA.
Gregory BroderickDepartment of Urology, Mayo Clinic Florida, Jacksonville, FL, USA.
Kelvin DaviesDepartment of Urology and Department of Physiology and Biophysics, Albert Einstein College of Medicine, New York, NY, USA.
Gerald BrockDivision of Urology, Department of Surgery, Western University, London, ON, Canada.
John MulhallSexual and Reproductive Medicine Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Ranjith RamasamyDepartment of Urology, Miller School of Medicine, University of Miami, Miami, FL, USA.
Trinity J BivalacquaThe James Buchanan Brady Urological Institute and Department of Urology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address: tbivala1@jhmi.edu.
Johns Hopkins Medicine · USUniversity of Miami · USAlbert Einstein College of Medicine · USBrigham Young University · USMayo Clinic in Florida · USMemorial Sloan Kettering Cancer Center · USThe University of Texas MD Anderson Cancer Center · USWestern University · CA

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

introductionCurrent non-invasive treatments for erectile dysfunction (ED) include oral medications, intracavernosal injections, and vacuum-assisted devices. Though these therapies work well for many, a subset of patients have contraindications or are unsatisfied with these options. Restorative therapies for ED are a new frontier of treatments focused on regenerating diseased tissue and providing a potential "cure" for ED.

aimThe aim of this position statement is to examine existing clinical trial data for restorative therapies and identify elements that require further research before widespread adoption.

methodsA literature review was performed to identify all clinical trials performed with regenerative therapy for ED. This includes treatments such as stem cell therapy (SCT), platelet rich plasma (PRP), and restorative related technologies like low-intensity shockwave therapy (LiSWT).

main outcome measuresMost clinical trials in restorative therapies were assessed for safety, feasibility, or efficacy. This included recording adverse events, changes in sexual function and erectile function questionnaires, and diagnostics measures.

resultsTo date there is an absence of robust clinical data supporting the efficacy of restorative therapies regarding ED, though technologies such as LiSWT have established relative safety.

conclusionsRestorative therapies are a promising technology that represents a new frontier of treatment geared towards reversing disease pathology rather than just treating symptoms. However, current published clinical studies are limited. Future work needs to be adequately powered, multi-center, randomized, sham/placebo-controlled trials in well-characterized patient populations to ensure safety and demonstrate efficacy. Until these studies are done, restorative therapies should be reserved for clinical trials and not offered in routine clinical practice. Liu JL, Chu KY, Gabrielson AT, et al. Restorative Therapies for Erectile Dysfunction: Position Statement From the Sexual Medicine Society of North America (SMSNA). J Sex Med 2021;9:100343.

Indexed as

Erectile dysfunctionLow intensity shock wave therapyPlatelet rich plasmaRestorative therapiesStem cell therapyStromal vascular fraction

Identifiers

PMID34000480
PMCPMC8240368
OpenAlexW3161336985

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.