ArticleNeuroImage2021
Identifying brain networks in synaptic density PET (
Article in NeuroImage, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Effects of escitalopram on synaptic density in the healthy human brain: a randomized controlled trial.Molecular psychiatry · 2023Trial
- Effects of Tasks on Functional Brain Connectivity Derived from Interindividual Correlations: Insights from Regional Homogeneity of Functional MRI Data.Brain connectivity · 2025Article
- Synaptic loss pattern is constrained by brain connectome and modulated by phosphorylated tau in Alzheimer's disease.Nature communications · 2025Article
- Effects of Tasks on Functional Brain Connectivity Derived from Inter-Individual Correlations: Insights from Regional Homogeneity of Functional MRI Data.bioRxiv : the preprint server for biology · 2025Article
- Molecular connectivity studies in neurotransmission: a scoping review.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- An In Vivo High-Resolution Human Brain Atlas of Synaptic Density.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Changes in microstructural similarity of hippocampal subfield circuits in pathological cognitive aging.Brain structure & function · 2024Article
- Synaptic density patterns in early Alzheimer's disease assessed by independent component analysis.Brain communications · 2024Article
- Synaptic density affects clinical severity via network dysfunction in syndromes associated with frontotemporal lobar degeneration.Nature communications · 2023Article
- A new framework for metabolic connectivity mapping using bolus [Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Article
- Functional Brain Networks to Evaluate Treatment Responses in Parkinson's Disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023Article
- PET imaging of animal models with depressive-like phenotypes.European journal of nuclear medicine and molecular imaging · 2023Review
- Brain connectomics: time for a molecular imaging perspective?Trends in cognitive sciences · 2023Review
- Linking resting-state network fluctuations with systems of coherent synaptic density: A multimodal fMRI andFrontiers in human neuroscience · 2023Article
- A review on multiple sclerosis prognostic findings from imaging, inflammation, and mental health studies.Frontiers in human neuroscience · 2023Review
- Intra and inter: Alterations in functional brain resting-state networks in patients with functional constipation.Frontiers in neuroscience · 2022Article
- Uncovering the link between synaptic density and mental illness through in vivo imaging.Journal of psychiatry & neuroscience : JPNArticle
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
backgroundThe human brain is inherently organized into distinct networks, as reported widely by resting-state functional magnetic resonance imaging (rs-fMRI), which are based on blood-oxygen-level-dependent (BOLD) signal fluctuations.
methodsThe aim of this study was to identify maximally independent brain source networks, i.e., "spatial patterns with common covariance across subjects", in
resultsThirteen source networks replicated across both samples. We determined that a model order of 18 components provided stable, replicable components, whereas estimations above 18 were not stable. Effects of sex were found in two ICs. Nine ICs showed age-related change, with 4 remaining significant after correction for multiple comparison.
conclusionThis study provides the first evidence that human brain synaptic density can be characterized into organized covariance patterns. Furthermore, we demonstrated that multiple synaptic density source networks are associated with age, which supports the potential utility of ICA to identify biologically relevant synaptic density source networks.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.