Evidence map›Paper›PMID 34000397›Full record

ArticleNeuroImage2021

Probabilistic mapping of human functional brain networks identifies regions of high group consensus.

Ally Dworetsky, Benjamin A Seitzman, Babatunde Adeyemo, Maital Neta, Rebecca S Coalson, Steven E Petersen, Caterina Gratton

Abstract read
In one paragraph

Article in NeuroImage, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Individualized Network Topography in Pre-adolescent Children and Adults Using Naturalistic Precision fMRI.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  3. Article
  4. Functional brain organization is stable within individuals across years.bioRxiv : the preprint server for biology · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Individualized Mapping of Functional Brain Networks in Older Adulthood.bioRxiv : the preprint server for biology · 2026
    Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Aging and the Spectral Properties of Brain Hemodynamics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ally DworetskyDepartment of Radiology, Washington University School of Medicine, USA; Department of Psychology, Northwestern University, USA.
Benjamin A SeitzmanDepartment of Neurology, Washington University School of Medicine, USA.
Babatunde AdeyemoDepartment of Neurology, Washington University School of Medicine, USA.
Maital NetaDepartment of Psychology, University of Nebraska-Lincoln, USA.
Rebecca S CoalsonDepartment of Radiology, Washington University School of Medicine, USA; Department of Neurology, Washington University School of Medicine, USA.
Steven E PetersenDepartment of Radiology, Washington University School of Medicine, USA; Department of Neurology, Washington University School of Medicine, USA; Department of Psychological and Brain Sciences, Washington University School of Medicine, USA; Department of Neuroscience, Washington University School of Medicine, USA; Department of Biomedical Engineering, Washington University School of Medicine, USA.
Caterina GrattonDepartment of Psychology, Northwestern University, USA; Department of Neurology, Northwestern University, USA; Interdepartmental Neuroscience Program, Northwestern University, USA.

Funding

Sources and Functional Consequences of Individual Differences in Human Functional Brain Networks Related to Controlled BehaviorR01MH118370 · NIMH · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI GRATTON, CATERINA · 2019 to 2023
$3.4M
Functional Brain Networks Mediating Individual Differences in Valence BiasR01MH111640 · NIMH · UNIVERSITY OF NEBRASKA LINCOLN · PI NETA, MAITAL · 2017 to 2022
$1.8M
NIMH NIH HHS R01 MH111640NIMH NIH HHS R01 MH118370
6 · The paper itself

Abstract

Many recent developments surrounding the functional network organization of the human brain have focused on data that have been averaged across groups of individuals. While such group-level approaches have shed considerable light on the brain's large-scale distributed systems, they conceal individual differences in network organization, which recent work has demonstrated to be common and widespread. This individual variability produces noise in group analyses, which may average together regions that are part of different functional systems across participants, limiting interpretability. However, cost and feasibility constraints may limit the possibility for individual-level mapping within studies. Here our goal was to leverage information about individual-level brain organization to probabilistically map common functional systems and identify locations of high inter-subject consensus for use in group analyses. We probabilistically mapped 14 functional networks in multiple datasets with relatively high amounts of data. All networks show "core" (high-probability) regions, but differ from one another in the extent of their higher-variability components. These patterns replicate well across four datasets with different participants and scanning parameters. We produced a set of high-probability regions of interest (ROIs) from these probabilistic maps; these and the probabilistic maps are made publicly available, together with a tool for querying the network membership probabilities associated with any given cortical location. These quantitative estimates and public tools may allow researchers to apply information about inter-subject consensus to their own fMRI studies, improving inferences about systems and their functional specializations.

Indexed as

IndividualityAdultBrain MappingCerebral CortexConnectomeDatasets as TopicFemaleHumansMagnetic Resonance ImagingMaleNerve NetProbabilityfMRIFunctional connectivityIndividual differencesNetworks

Identifiers

PMID34000397
PMCPMC8296467

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.