Evidence map›Paper›PMID 34000280›Full record

ArticleAmerican journal of ophthalmology2021

Assessing Photoreceptor Status in Retinal Dystrophies: From High-Resolution Imaging to Functional Vision.

José-Alain Sahel, Kate Grieve, Chloé Pagot, Colas Authié, Saddek Mohand-Said, Michel Paques, Isabelle Audo, Karine Becker, Anne-Elisabeth Chaumet-Riffaud, Line Azoulay and 6 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of ophthalmology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Observational
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Overview of Retinal Gene Therapy: Current Status and Future Challenges.Cold Spring Harbor perspectives in medicine · 2023
    Review
  12. Adaptive Optics Imaging of Inherited Retinal Disease.Cold Spring Harbor perspectives in medicine · 2023
    Review
  13. Review
  14. The Importance of Natural History Studies in Inherited Retinal Diseases.Cold Spring Harbor perspectives in medicine · 2023
    Review
  15. Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 1 institution in 2 countries.

José-Alain SahelFrom the Department of Ophthalmology, University of Pittsburgh School of Medicine and Medical Center, Pittsburgh, Pennsylvania, USA (J.-A.S.); Sorbonne Université, Paris, France (J.-A.S.); Quinze Vingts National Ophthalmology Hospital, Paris, France (J.A.S., K.G., S.M.-S., M.P., I.A., A.-E.C.-R., L.A.); StreetLab - Institut de la Vision, Paris, France (C.P., C.A., K.B., E.G.); and Institut de la Vision, Sorbonne Université, Inserm, CNRS Paris, France (M.P., I.A., T.L., C.Z., S.P., D.D., K.M.).. Electronic address: sahelja@upmc.edu.
Kate GrieveFrom the Department of Ophthalmology, University of Pittsburgh School of Medicine and Medical Center, Pittsburgh, Pennsylvania, USA (J.-A.S.); Sorbonne Université, Paris, France (J.-A.S.); Quinze Vingts National Ophthalmology Hospital, Paris, France (J.A.S., K.G., S.M.-S., M.P., I.A., A.-E.C.-R., L.A.); StreetLab - Institut de la Vision, Paris, France (C.P., C.A., K.B., E.G.); and Institut de la Vision, Sorbonne Université, Inserm, CNRS Paris, France (M.P., I.A., T.L., C.Z., S.P., D.D., K.M.).
Chloé PagotFrom the Department of Ophthalmology, University of Pittsburgh School of Medicine and Medical Center, Pittsburgh, Pennsylvania, USA (J.-A.S.); Sorbonne Université, Paris, France (J.-A.S.); Quinze Vingts National Ophthalmology Hospital, Paris, France (J.A.S., K.G., S.M.-S., M.P., I.A., A.-E.C.-R., L.A.); StreetLab - Institut de la Vision, Paris, France (C.P., C.A., K.B., E.G.); and Institut de la Vision, Sorbonne Université, Inserm, CNRS Paris, France (M.P., I.A., T.L., C.Z., S.P., D.D., K.M.).
Colas AuthiéFrom the Department of Ophthalmology, University of Pittsburgh School of Medicine and Medical Center, Pittsburgh, Pennsylvania, USA (J.-A.S.); Sorbonne Université, Paris, France (J.-A.S.); Quinze Vingts National Ophthalmology Hospital, Paris, France (J.A.S., K.G., S.M.-S., M.P., I.A., A.-E.C.-R., L.A.); StreetLab - Institut de la Vision, Paris, France (C.P., C.A., K.B., E.G.); and Institut de la Vision, Sorbonne Université, Inserm, CNRS Paris, France (M.P., I.A., T.L., C.Z., S.P., D.D., K.M.).
Saddek Mohand-SaidFrom the Department of Ophthalmology, University of Pittsburgh School of Medicine and Medical Center, Pittsburgh, Pennsylvania, USA (J.-A.S.); Sorbonne Université, Paris, France (J.-A.S.); Quinze Vingts National Ophthalmology Hospital, Paris, France (J.A.S., K.G., S.M.-S., M.P., I.A., A.-E.C.-R., L.A.); StreetLab - Institut de la Vision, Paris, France (C.P., C.A., K.B., E.G.); and Institut de la Vision, Sorbonne Université, Inserm, CNRS Paris, France (M.P., I.A., T.L., C.Z., S.P., D.D., K.M.).
Michel PaquesFrom the Department of Ophthalmology, University of Pittsburgh School of Medicine and Medical Center, Pittsburgh, Pennsylvania, USA (J.-A.S.); Sorbonne Université, Paris, France (J.-A.S.); Quinze Vingts National Ophthalmology Hospital, Paris, France (J.A.S., K.G., S.M.-S., M.P., I.A., A.-E.C.-R., L.A.); StreetLab - Institut de la Vision, Paris, France (C.P., C.A., K.B., E.G.); and Institut de la Vision, Sorbonne Université, Inserm, CNRS Paris, France (M.P., I.A., T.L., C.Z., S.P., D.D., K.M.).
Isabelle AudoFrom the Department of Ophthalmology, University of Pittsburgh School of Medicine and Medical Center, Pittsburgh, Pennsylvania, USA (J.-A.S.); Sorbonne Université, Paris, France (J.-A.S.); Quinze Vingts National Ophthalmology Hospital, Paris, France (J.A.S., K.G., S.M.-S., M.P., I.A., A.-E.C.-R., L.A.); StreetLab - Institut de la Vision, Paris, France (C.P., C.A., K.B., E.G.); and Institut de la Vision, Sorbonne Université, Inserm, CNRS Paris, France (M.P., I.A., T.L., C.Z., S.P., D.D., K.M.).
Karine BeckerFrom the Department of Ophthalmology, University of Pittsburgh School of Medicine and Medical Center, Pittsburgh, Pennsylvania, USA (J.-A.S.); Sorbonne Université, Paris, France (J.-A.S.); Quinze Vingts National Ophthalmology Hospital, Paris, France (J.A.S., K.G., S.M.-S., M.P., I.A., A.-E.C.-R., L.A.); StreetLab - Institut de la Vision, Paris, France (C.P., C.A., K.B., E.G.); and Institut de la Vision, Sorbonne Université, Inserm, CNRS Paris, France (M.P., I.A., T.L., C.Z., S.P., D.D., K.M.).
Anne-Elisabeth Chaumet-RiffaudFrom the Department of Ophthalmology, University of Pittsburgh School of Medicine and Medical Center, Pittsburgh, Pennsylvania, USA (J.-A.S.); Sorbonne Université, Paris, France (J.-A.S.); Quinze Vingts National Ophthalmology Hospital, Paris, France (J.A.S., K.G., S.M.-S., M.P., I.A., A.-E.C.-R., L.A.); StreetLab - Institut de la Vision, Paris, France (C.P., C.A., K.B., E.G.); and Institut de la Vision, Sorbonne Université, Inserm, CNRS Paris, France (M.P., I.A., T.L., C.Z., S.P., D.D., K.M.).
Line AzoulayFrom the Department of Ophthalmology, University of Pittsburgh School of Medicine and Medical Center, Pittsburgh, Pennsylvania, USA (J.-A.S.); Sorbonne Université, Paris, France (J.-A.S.); Quinze Vingts National Ophthalmology Hospital, Paris, France (J.A.S., K.G., S.M.-S., M.P., I.A., A.-E.C.-R., L.A.); StreetLab - Institut de la Vision, Paris, France (C.P., C.A., K.B., E.G.); and Institut de la Vision, Sorbonne Université, Inserm, CNRS Paris, France (M.P., I.A., T.L., C.Z., S.P., D.D., K.M.).
Emmanuel GutmanFrom the Department of Ophthalmology, University of Pittsburgh School of Medicine and Medical Center, Pittsburgh, Pennsylvania, USA (J.-A.S.); Sorbonne Université, Paris, France (J.-A.S.); Quinze Vingts National Ophthalmology Hospital, Paris, France (J.A.S., K.G., S.M.-S., M.P., I.A., A.-E.C.-R., L.A.); StreetLab - Institut de la Vision, Paris, France (C.P., C.A., K.B., E.G.); and Institut de la Vision, Sorbonne Université, Inserm, CNRS Paris, France (M.P., I.A., T.L., C.Z., S.P., D.D., K.M.).
Thierry LéveillardFrom the Department of Ophthalmology, University of Pittsburgh School of Medicine and Medical Center, Pittsburgh, Pennsylvania, USA (J.-A.S.); Sorbonne Université, Paris, France (J.-A.S.); Quinze Vingts National Ophthalmology Hospital, Paris, France (J.A.S., K.G., S.M.-S., M.P., I.A., A.-E.C.-R., L.A.); StreetLab - Institut de la Vision, Paris, France (C.P., C.A., K.B., E.G.); and Institut de la Vision, Sorbonne Université, Inserm, CNRS Paris, France (M.P., I.A., T.L., C.Z., S.P., D.D., K.M.).
Christina ZeitzFrom the Department of Ophthalmology, University of Pittsburgh School of Medicine and Medical Center, Pittsburgh, Pennsylvania, USA (J.-A.S.); Sorbonne Université, Paris, France (J.-A.S.); Quinze Vingts National Ophthalmology Hospital, Paris, France (J.A.S., K.G., S.M.-S., M.P., I.A., A.-E.C.-R., L.A.); StreetLab - Institut de la Vision, Paris, France (C.P., C.A., K.B., E.G.); and Institut de la Vision, Sorbonne Université, Inserm, CNRS Paris, France (M.P., I.A., T.L., C.Z., S.P., D.D., K.M.).
Serge PicaudFrom the Department of Ophthalmology, University of Pittsburgh School of Medicine and Medical Center, Pittsburgh, Pennsylvania, USA (J.-A.S.); Sorbonne Université, Paris, France (J.-A.S.); Quinze Vingts National Ophthalmology Hospital, Paris, France (J.A.S., K.G., S.M.-S., M.P., I.A., A.-E.C.-R., L.A.); StreetLab - Institut de la Vision, Paris, France (C.P., C.A., K.B., E.G.); and Institut de la Vision, Sorbonne Université, Inserm, CNRS Paris, France (M.P., I.A., T.L., C.Z., S.P., D.D., K.M.).
Deniz DalkaraFrom the Department of Ophthalmology, University of Pittsburgh School of Medicine and Medical Center, Pittsburgh, Pennsylvania, USA (J.-A.S.); Sorbonne Université, Paris, France (J.-A.S.); Quinze Vingts National Ophthalmology Hospital, Paris, France (J.A.S., K.G., S.M.-S., M.P., I.A., A.-E.C.-R., L.A.); StreetLab - Institut de la Vision, Paris, France (C.P., C.A., K.B., E.G.); and Institut de la Vision, Sorbonne Université, Inserm, CNRS Paris, France (M.P., I.A., T.L., C.Z., S.P., D.D., K.M.).
Katia MarazovaFrom the Department of Ophthalmology, University of Pittsburgh School of Medicine and Medical Center, Pittsburgh, Pennsylvania, USA (J.-A.S.); Sorbonne Université, Paris, France (J.-A.S.); Quinze Vingts National Ophthalmology Hospital, Paris, France (J.A.S., K.G., S.M.-S., M.P., I.A., A.-E.C.-R., L.A.); StreetLab - Institut de la Vision, Paris, France (C.P., C.A., K.B., E.G.); and Institut de la Vision, Sorbonne Université, Inserm, CNRS Paris, France (M.P., I.A., T.L., C.Z., S.P., D.D., K.M.).
Centre National de la Recherche Scientifique · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo describe the value of integrating phenotype/genotype data, disease staging, and evaluation of functional vision in patient-centered management of retinal dystrophies.

methods(1) Cross-sectional structure-function and retrospective longitudinal studies to assess the correlations between standard fundus autofluorescence (FAF), optical coherence tomography, visual acuity (VA), and perimetry (visual field [VF]) examinations to evaluate photoreceptor functional loss in a cohort of patients with rod-cone dystrophy (RCD); (2) flood-illumination adaptive optics (FIAO) imaging focusing on photoreceptor misalignment and orientation of outer segments; and (3) evaluation of the impact of visual impairment in daily life activities, based on functional (visual and mobility) vision assessment in a naturalistic environment in visually impaired subjects with RCD and subjects treated with Luxturna

resultsThe results of the cross-sectional transversal study showed that (1) VA and macular sensitivity were weakly correlated with the structural variables; and (2) functional impairment (VF) was correlated with reduction of anatomical markers of photoreceptor structure and increased width of autofluorescent ring. The dimensions of the ring of increased FAF evolved faster. Other criteria that differed among groups were the lengths of the ellipsoid zone, the external limiting membrane, and the foveal thickness. FIAO revealed a variety of phenotypes: paradoxical visibility of foveal cones; heterogeneous brightness of cones; dim, inner segment-like, and RPE-like mosaic. Directional illumination by varying orientation of incident light (Stiles-Crawford effect) and the amount of side illumination (gaze-dependent imaging) affected photoreceptor visibility. Mobility assessment under different lighting conditions showed correlation with VF, VA, contrast sensitivity (CS), and dark adaptation, with different predictive values depending on mobility study paradigms and illumination level. At high illumination level (235 lux), VF was a predictor for all mobility performance models. Under low illumination (1 and 2 lux), VF was the most significant predictor of mobility performance variables, while CS best explained the number of collisions and segments. In subjects treated with Luxturna

conclusionsOur results suggest the benefit of development and implementation of quantitative and reproducible tools to evaluate the status of photoreceptors and the impact of both visual impairment and novel therapies in real-life conditions. NOTE: Publication of this article is sponsored by the American Ophthalmological Society.

Indexed as

Retinal Cone Photoreceptor CellsRetinal DystrophiesCross-Sectional StudiesHumansRetrospective StudiesTomography, Optical Coherence

Identifiers

PMID34000280
PMCPMC8682761
OpenAlexW3163673421

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.