ArticleCurrent protocols2021
SHIRPA as a Neurological Screening Battery in Mice.
Article in Current protocols, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 26 citations in OpenAlex.
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- Neurobehavioral and metabolic effects of prenatal low-dose chlorpyrifos in C57BL/6J mice.Neurotoxicology · 2025Article
- Optimized Mouse Model of Sepsis-Associated Encephalopathy: A Rational Standard Based on Modified SHIRPA Score and Neurobehaviors in Mice.CNS neuroscience & therapeutics · 2025Article
- Alpha-synuclein null mutation exacerbates the phenotype of a model of Menkes disease in female mice.Frontiers in neuroscience · 2025Article
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- Improving laboratory animal genetic reporting: LAG-R guidelines.Nature communications · 2024Review
- Arbovirus infection increases the risk for the development of neurodegenerative disease pathology in the murine model.Brain, behavior, & immunity - health · 2024Article
- A sex-specific effect of MFrontiers in molecular neuroscience · 2024Article
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- Neuromotor deficits and altered physiological responses to repeated exertional heat stroke exposures in mice.American journal of physiology. Regulatory, integrative and comparative physiology · 2022Article
- Autophagy regulates neuronal excitability by controlling cAMP/protein kinase A signaling at the synapse.The EMBO journal · 2022Article
- Sepsis Encephalopathy Is Partly Mediated by miR370-3p-Induced Mitochondrial Injury but Attenuated by BAM15 in Cecal Ligation and Puncture Sepsis Male Mice.International journal of molecular sciences · 2022Article
- C-type natriuretic peptide preserves central neurological function by maintaining blood-brain barrier integrity.Frontiers in molecular neuroscience · 2022Article
- Roadbumps at the Crossroads of Integrating Behavioral andFrontiers in toxicology · 2022Review
Corrections and comments
- Erratum issued
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The SmithKline, Harwell, Imperial College, Royal Hospital, Phenotype Assessment (SHIRPA) is a rapid battery of tests comprising 42 measurements of motor activity, coordination, postural control, muscle tone, autonomic functions, and emotional reactivity, as well as reflexes dependent on visual, auditory, and tactile modalities. Individual scores in SHIRPA are sensitive in detecting phenotypes of several experimental models of neural disease, especially cerebellar degeneration and Alzheimer disease, and combined subscores have been useful in estimating the impact of vascular anomalies and exposure to infectious agents. In cerebellar degeneration, weak forelimb grip, impaired wire maneuver and air righting, and negative geotaxis appear as prevalent features. Most of the measures in the battery are susceptible to change after gene modifications or physiological alterations. SHIRPA can be used both in adult mice and mice in the preweaning period to screen for sensorimotor function and emotional reactivity, not selective attention or memory. © 2021 Wiley Periodicals LLC Basic Protocol: Step-by-step procedure for SHIRPA.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.