Evidence map›Paper›PMID 34000072›Full record

Trial reportAmerican journal of hematology2021

Lactate dehydrogenase to carboxyhemoglobin ratio as a biomarker of heme release to heme processing is associated with higher tricuspid regurgitant jet velocity and early death in sickle cell disease.

Annelies J van Vuren, Caterina P Minniti, Laurel Mendelsohn, John H Baird, Gregory J Kato, Eduard J van Beers

Open access · hybridAbstract readClinical TrialLetter
PubMed Full text at PMC Publisher
In one paragraph

Trial report in American journal of hematology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 2 countries.

Annelies J van VurenVan Creveldkliniek, Division of Internal Medicine and Dermatology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.ORCID 0000-0002-4258-3836
Caterina P MinnitiDivision of Hematology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, New York, USA.
Laurel MendelsohnSickle Cell Branch, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.
John H BairdDivision of Hematology, Department of Medicine, Stanford University, Stanford, California, USA.
Gregory J KatoHeart, Lung and Blood Vascular Medicine Institute and the Division of Hematology-Oncology, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID 0000-0003-4465-3217
Eduard J van BeersVan Creveldkliniek, Division of Internal Medicine and Dermatology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Utrecht University · NLAlbert Einstein College of Medicine · USNational Institutes of Health · USStanford University · USUniversity of Pittsburgh · US

Funding

Cardiopulmonary Function Assessment and NO Based Therapies for SCD Pts with PAHZIAHL006015 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI KATO, GREGORY · 2009 to 2012
$530k
Plasma Biomarkers of Sickle Cell Pulmonary HypertensionZIAHL006162 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI KATO, GREGORY · 2012 to 2013
$506k
Division of Intramural Research at the National Heart, Lung and Blood Institute HL006013Division of Intramural Research at the National Heart, Lung and Blood Institute HL006014Division of Intramural Research at the National Heart, Lung and Blood Institute HL006015Division of Intramural Research at the National Heart, Lung and Blood Institute HL006162
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AdultAnemia, Sickle CellBiomarkersCarbon MonoxideCarboxyhemoglobinHemeHemolysisHumansL-Lactate DehydrogenaseTricuspid Valve InsufficiencyBiomarkersCarbon MonoxideCarboxyhemoglobinHemeL-Lactate Dehydrogenase

Identifiers

PMID34000072
PMCPMC8453521
OpenAlexW3162053342

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.