Evidence map›Paper›PMID 33999698›Full record

Trial reportCirculation. Arrhythmia and electrophysiology2021

Durable Physiological Changes and Decreased Syncope Burden 12 Months After Unifocal Right-Sided Ablation Under Computed Tomographic Guidance in Patients With Neurally Mediated Syncope or Functional Sinus Node Dysfunction.

Philippe Debruyne, Tom Rossenbacker, Luc Janssens, Christine Collienne, Joris Ector, Peter Haemers, Jean-Benoît le Polain de Waroux, Christine Bazelmans, Tim Boussy, William Wijns

Registry-linked trialOpen access · hybridAbstract readClinical TrialComparative StudyMulticenter Study
In one paragraph

Trial report in Circulation. Arrhythmia and electrophysiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06276816 (Cardiac Denervation Ablation Strategy for Severe Sinus Bradycardia), which is not on this map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
7.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06276816 unknown statusnot on this mapstarted 2023, after this paper: background citation

Cardiac Denervation Ablation Strategy for Severe Sinus Bradycardia

TypeobservationalSponsorChina National Center for Cardiovascular DiseasesRan2023 to 2024Enrolled88ConditionsSinus Bradycardia
3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.

  1. Cardioneuroablation for the treatment of reflex syncope and functional bradyarrhythmias: A Scientific Statement of the European Heart Rhythm Association (EHRA) of the ESC, the Heart Rhythm Society (HRS), the Asia Pacific Heart Rhythm Society (APHRS) and the Latin American Heart Rhythm Society (LAHRS).Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2024
    Guideline
  2. Article
  3. Convolutional neural network for real‑time localization of ganglionated plexi from bipolar intracardiac electrograms.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2026
    Article
  4. Cardioneuroablation versus cardiac pacemaker in the management of dominant cardioinhibitory vasovagal syncope: a retrospective cohort study.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2026
    Article
  5. Article
  6. Differential effects of right atrial ablation sites on vagal modulation of the sinus node during cardioneuroablation.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2026
    Article
  7. Review
  8. A tailored approach to cardioneuroablation for reflex syncope and functional bradycardia: results from the ELEGANCE multicentre study.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026
    Article
  9. Review
  10. Intracardiac echocardiography guided anatomical approach to cardioneuroablation: feasibility and outcomes.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025
    Article
  11. Review
  12. Step-by-step application of a new ganglionated plexus mapping method in a patient with vasovagal syncope.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2025
    Article
  13. Fluoroscopy-free cardioneuroablation for functional bradycardia: a single-center experience.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2025
    Observational
  14. Review
  15. Article
  16. Review
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 3 countries.

Philippe DebruyneDepartment of Cardiology, Imeldaziekenhuis, Bonheiden, Belgium (P.D., T.R., L.J.).
Tom RossenbackerDepartment of Cardiology, Imeldaziekenhuis, Bonheiden, Belgium (P.D., T.R., L.J.).
Luc JanssensDepartment of Cardiology, Imeldaziekenhuis, Bonheiden, Belgium (P.D., T.R., L.J.).
Christine CollienneDepartment of Intensive Care, Cliniques Universitaires Saint-Luc, Woluwe, Belgium (C.C.).
Joris EctorDepartment of Cardiology, University of Leuven, Belgium (J.E., P.H.).
Peter HaemersDepartment of Cardiology, University of Leuven, Belgium (J.E., P.H.).
Jean-Benoît le Polain de WarouxDepartment of Cardiology, AZ Sint-Jan Brugge-Oostende AV, Belgium (J.-B.l.P.d.W.).
Christine BazelmansDepartment of Cardiology, Biotronik Belgium, Vilvoorde (C.B.).
Tim BoussyDepartment of Cardiology, AZ Groeninge, Kortrijk, Belgium (T.B.).
William WijnsThe Lambe Institute for Translational Medicine and Curam, National University of Ireland, Galway and Saolta University Healthcare Group (W.W.).
Cliniques Universitaires Saint-Luc · BEImelda Hospital · BEKU Leuven · BEAZ Groeninge · BEAZ Sint-Jan · BEBiotronik (Switzerland) · CHSaolta University Health Care Group · IE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

[Figure: see text].

Indexed as

AdolescentAdultAgedAutonomic Nervous SystemCatheter AblationFemaleFollow-Up StudiesHeart Conduction SystemHeart RateHumansMaleMiddle AgedPostoperative ComplicationsProspective StudiesSick Sinus SyndromeSurgery, Computer-Assistedautonomic nervous systemcohort studiesexercise testheart ratesyncope

Identifiers

PMID33999698
PMCPMC8208097
OpenAlexW3162303203

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.