Evidence map›Paper›PMID 33999487›Full record

SynthesisAddiction (Abingdon, England)2022

Causal mechanisms proposed for the alcohol harm paradox-a systematic review.

Jennifer Boyd, Olivia Sexton, Colin Angus, Petra Meier, Robin C Purshouse, John Holmes

Abstract readSystematic Review
In one paragraph

Synthesis in Addiction (Abingdon, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

75 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Treatment Needs of Patients With Severe Alcohol Use Disorders.Indian journal of psychological medicine · 2026
    Article
  4. Article
  5. A Data-Driven Exploratory Analysis of the Alcohol-Harm Paradox in South-East Wales.International journal of environmental research and public health · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

15 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jennifer BoydSchool of Health and Related Research, University of Sheffield, Sheffield, UK.ORCID 0000-0001-8780-3196
Olivia SextonSchool of Health and Related Research, University of Sheffield, Sheffield, UK.ORCID 0000-0003-0504-8313
Colin AngusSchool of Health and Related Research, University of Sheffield, Sheffield, UK.ORCID 0000-0003-0529-4135
Petra MeierMRC/CSO Social and Public Health Sciences Unit, University of Glasgow, Glasgow, UK.ORCID 0000-0001-5354-1933
Robin C PurshouseDepartment of Automatic Control and Systems Engineering, University of Sheffield, Sheffield, UK.ORCID 0000-0001-5880-1925
John HolmesSchool of Health and Related Research, University of Sheffield, Sheffield, UK.ORCID 0000-0001-9283-2151

Funding

Calibrated Agent Simulations for Combined Analysis of Drinking Etiologies (CASCADE)R01AA024443 · NIAAA · UNIVERSITY OF SHEFFIELD · PI PURSHOUSE, ROBIN · 2016 to 2020
$2.3M
Chief Scientist Office SPHSU20Medical Research Council MC_UU_00022/5NIAAA NIH HHS R01 AA024443Wellcome TrustWellcome Trust 108903/B/15/Z
6 · The paper itself

Abstract

BACKGROUND AND

aimsThe alcohol harm paradox (AHP) posits that disadvantaged groups suffer from higher rates of alcohol-related harm compared with advantaged groups, despite reporting similar or lower levels of consumption on average. The causes of this relationship remain unclear. This study aimed to identify explanations proposed for the AHP. Secondary aims were to review the existing evidence for those explanations and investigate whether authors linked explanations to one another.

methodsThis was a systematic review. We searched MEDLINE (1946-January 2021), EMBASE (1974-January 2021) and PsycINFO (1967-January 2021), supplemented with manual searching of grey literature. Included papers either explored the causes of the AHP or investigated the relationship between alcohol consumption, alcohol-related harm and socio-economic position. Papers were set in Organization for Economic Cooperation and Development high-income countries. Explanations extracted for analysis could be evidenced in the empirical results or suggested by researchers in their narrative. Inductive thematic analysis was applied to group explanations.

resultsSeventy-nine papers met the inclusion criteria and initial coding revealed that these papers contained 41 distinct explanations for the AHP. Following inductive thematic analysis, these explanations were grouped into 16 themes within six broad domains: individual, life-style, contextual, disadvantage, upstream and artefactual. Explanations related to risk behaviours, which fitted within the life-style domain, were the most frequently proposed (n = 51) and analysed (n = 21).

conclusionsWhile there are many potential explanations for the alcohol harm paradox, most research focuses on risk behaviours while other explanations lack empirical testing.

Indexed as

Alcohol DrinkingIncomeCausalityHumansLife StyleAlcohol consumptionalcohol-related harmcausal mechanismsdisadvantagehealth inequalitiesmorbiditymortalitysocio-economic position

Identifiers

PMID33999487
PMCPMC8595457

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.