ArticleCanadian journal of public health = Revue canadienne de sante publique2021
SARS-CoV-2 seroprevalence among blood donors in Québec, and analysis of symptoms associated with seropositivity: a nested case-control study.
Article in Canadian journal of public health = Revue canadienne de sante publique, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Incidence of SARS-CoV-2 during the Omicron wave: Results of a longitudinal serosurvey in Québec, Canada.Canadian journal of public health = Revue canadienne de sante publique · 2024Article
- Canada's approach to SARS-CoV-2 sero-surveillance: Lessons learned for routine surveillance and future pandemics.Canadian journal of public health = Revue canadienne de sante publique · 2024Article
- Seroprevalence of SARS-CoV-2 IgG in blood donors in a teaching institute from Western part of Maharashtra.Journal of family medicine and primary care · 2024Article
- The changing profile of SARS-CoV-2 serology in Irish blood donors.Global epidemiology · 2023Article
- Cross-Canada Variability in Blood Donor SARS-CoV-2 Seroprevalence by Social Determinants of Health.Microbiology spectrum · 2023Article
- COVID-19 vaccine humoral response in frequent platelet donors with plateletpheresis-associated lymphopenia.Transfusion · 2022Article
- Seroprevalence of SARS-CoV-2 antibodies among blood donors in Québec: an update from a serial cross-sectional study.Canadian journal of public health = Revue canadienne de sante publique · 2022Article
- Seroprevalence of SARS-CoV-2 antibodies in blood donors during the third wave of infection in Campeche Mexico.Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis · 2022Article
- Changing Patterns of SARS-CoV-2 Seroprevalence among Canadian Blood Donors during the Vaccine Era.Microbiology spectrum · 2022Article
- Canadian blood suppliers: An expanding role in public health surveillance?Canada communicable disease report = Releve des maladies transmissibles au Canada · 2022Article
- Positive anti-SARS-CoV-2 rapid serological test results among asymptomatic blood donors.Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine · 2022Article
- Seroprevalence of COVID-19 in Blood Donors: A Systematic Review and Meta-Analysis.Advances in virology · 2022Review
- Confirmed circulation of SARS-CoV-2 in Irish blood donors prior to first national notification of infection.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2022Article
- IgG antibodies to SARS-CoV-2 in asymptomatic blood donors at two time points in Karachi.PloS one · 2022Article
- Article
- Seroprevalence of SARS-CoV-2 Antibodies Among Children in School and Day Care in Montreal, Canada.JAMA network open · 2021Article
- Sero-prevalence of SARS-CoV-2 antibodies in blood donors during the third wave of infection in Norway, winter/spring 2021.Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis · 2021Article
- Article
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17 authors.
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Abstract
objectivesA substantial proportion of individuals infected with SARS-CoV-2 do not experience noticeable symptoms typical of COVID-19. Our objectives were to evaluate the impact of the first wave of the pandemic in Québec by measuring SARS-CoV-2 antibody seroprevalence in a convenience sample of healthy blood donors and to study the association between seropositivity and the occurrence of COVID-19 symptoms.
methodsThe study design was a cross-sectional serological survey with a nested case-control study. Residual blood samples from donations collected between May 25 and July 9, 2020 (well before vaccination rollout) in the province of Québec were tested for anti-Spike RBD antibodies by ELISA. Seropositive donors and a control group of seronegative donors were questioned about prior COVID-19 symptoms. All qualified blood donors were eligible for participation.
resultsA total of 7691 blood donors were included in the study. After adjustments, the seroprevalence rate was 2.2% (95% CI 1.9-2.6). Seropositive donors reported one or more symptoms in a proportion of 52.2% (95% CI 44.2-60.1); this proportion was 19.1% (95% CI 13.4-26.1) among seronegative donors, suggesting that approximately 50-66% of all infections were asymptomatic. Univariate analysis of associations between symptoms and seropositivity revealed that except for rhinorrhea, all symptoms were significantly associated with seropositivity.
conclusionAssuming that blood donors are fairly representative of the general adult population, this study shows that less than 3% of 18-69-year-olds have been infected during the first wave of the pandemic in the province of Québec. Our data also confirm that many infections escaped detection, including a substantial proportion that were asymptomatic.
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