Evidence map›Paper›PMID 33999295›Full record

ArticleJournal of materials science. Materials in medicine2021

Development and physicochemical characterization of novel porous phosphate glass bone graft substitute and in vitro comparison with xenograft.

Niketa Chauhan, Nilay Lakhkar, Amol Chaudhari

Abstract readComparative Study
In one paragraph

Article in Journal of materials science. Materials in medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Niketa ChauhanSynThera Biomedical Pvt. Ltd. 100, NCL Innovation Park, Dr. Homi Bhabha Road, Pashan, Pune, Maharashtra, 411008, India.ORCID http://orcid.org/0000-0003-3155-1916
Nilay LakhkarSynThera Biomedical Pvt. Ltd. 100, NCL Innovation Park, Dr. Homi Bhabha Road, Pashan, Pune, Maharashtra, 411008, India.ORCID http://orcid.org/0000-0001-9309-0348
Amol ChaudhariSynThera Biomedical Pvt. Ltd. 100, NCL Innovation Park, Dr. Homi Bhabha Road, Pashan, Pune, Maharashtra, 411008, India. amol.chaudhari1911@gmail.com.ORCID http://orcid.org/0000-0002-9072-5835

Funding

BIRAC BIRAC/KIIT0065/BIG-07/15
6 · The paper itself

Abstract

The process of bone regeneration in bone grafting procedures is greatly influenced by the physicochemical properties of the bone graft substitute. In this study, porous phosphate glass (PPG) morsels were developed and their physicochemical properties such as degradation, crystallinity, organic content, surface topography, particle size and porosity were evaluated using various analytical methods. The in vitro cytotoxicity of the PPG morsels was assessed and the interaction of the PPG morsels with Dental Pulp Stem Cells (DPSCs) was studied by measuring cell proliferation and cell penetration depth. The cell-material interactions between PPG morsels and a commercially available xenograft (XG) were compared. The PPG morsels were observed to be amorphous, biocompatible and highly porous (porosity = 58.45%). From in vitro experiments, PPG morsels were observed to be non-cytotoxic and showed better cell proliferation. The internal surface of PPG was easily accessible to the cells compared to XG.

Indexed as

Bone SubstitutesBiocompatible MaterialsBone RegenerationBone TransplantationCell DifferentiationCell LineageCell ProliferationCell SurvivalDental PulpGlassHumansIn Vitro TechniquesMicroscopy, ConfocalMicroscopy, Electron, ScanningOsteogenesisParticle SizeBiocompatible MaterialsBone SubstitutesPhosphates

Identifiers

PMID33999295
PMCPMC8128851

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.