ArticleNucleic acids research2021
A novel bipartite antitermination system widespread in conjugative elements of Gram-positive bacteria.
Article in Nucleic acids research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 13 citations in OpenAlex.
- Expression of conjugation genes is controlled by a novel zipper-type transcriptional attenuation mechanism.Nucleic acids research · 2026Article
- Article
- Transcription termination and antitermination are critical for the fitness and function of the integrative and conjugative element Tn916.PLoS genetics · 2024Article
- Genetic Engineering of Bacillus subtilis Using Competence-Induced Homologous Recombination Techniques.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Extraordinary long-stem confers resistance of intrinsic terminators to processive antitermination.Nucleic acids research · 2023Article
- Conjugation Operons in Gram-Positive Bacteria with and without Antitermination Systems.Microorganisms · 2022Article
- pLS20 is the archetype of a new family of conjugative plasmids harboured byNAR genomics and bioinformatics · 2021Article
- Establishment Genes Present on pLS20 Family of Conjugative Plasmids Are Regulated in Two Different Ways.Microorganisms · 2021Article
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
Transcriptional regulation allows adaptive and coordinated gene expression, and is essential for life. Processive antitermination systems alter the transcription elongation complex to allow the RNA polymerase to read through multiple terminators in an operon. Here, we describe the discovery of a novel bipartite antitermination system that is widespread among conjugative elements from Gram-positive bacteria, which we named conAn. This system is composed of a large RNA element that exerts antitermination, and a protein that functions as a processivity factor. Besides allowing coordinated expression of very long operons, we show that these systems allow differential expression of genes within an operon, and probably contribute to strict regulation of the conjugation genes by minimizing the effects of spurious transcription. Mechanistic features of the conAn system are likely to decisively influence its host range, with important implications for the spread of antibiotic resistance and virulence genes.
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