Evidence map›Paper›PMID 33998869›Full record

ArticleCannabis and cannabinoid research2021

Cannabinoid-2 Agonism with AM2301 Mitigates Morphine-Induced Respiratory Depression.

Beth M Wiese, Erika Liktor-Busa, Aidan Levine, Sarah A Couture, Spyros P Nikas, Lipin Ji, Yingpeng Liu, Kenneth Mackie, Alexandros Makriyannis, Tally M Largent-Milnes and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Cannabis and cannabinoid research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

  1. CBPharmacological research · 2025
    Article
  2. Article
  3. ΔCardiovascular toxicology · 2023
    Article
  4. Article
  5. The endocannabinoid system and breathing.Frontiers in neuroscience · 2023
    Review
  6. Article
  7. Cannabinoid CBNeuropharmacology · 2021
    Article
  8. History of Respiratory Stimulants.Journal of pain research · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Beth M WieseDepartment of Pharmacology, University of Arizona, Tucson, Arizona, USA.
Erika Liktor-BusaDepartment of Pharmacology, University of Arizona, Tucson, Arizona, USA.
Aidan LevineDepartment of Pharmacology, University of Arizona, Tucson, Arizona, USA.
Sarah A CoutureDepartment of Pharmacology, University of Arizona, Tucson, Arizona, USA.
Spyros P NikasChemistry and Chemical Biology, Bouve College Health Sciences-Center for Drug Discovery, Northeastern University, Boston, Massachusetts, USA.
Lipin JiChemistry and Chemical Biology, Bouve College Health Sciences-Center for Drug Discovery, Northeastern University, Boston, Massachusetts, USA.
Yingpeng LiuChemistry and Chemical Biology, Bouve College Health Sciences-Center for Drug Discovery, Northeastern University, Boston, Massachusetts, USA.
Kenneth MackieDepartment of Psychological and Brain Sciences, Indiana University Bloomington, Bloomington, Indiana, USA.
Alexandros MakriyannisChemistry and Chemical Biology, Bouve College Health Sciences-Center for Drug Discovery, Northeastern University, Boston, Massachusetts, USA.
Tally M Largent-MilnesDepartment of Pharmacology, University of Arizona, Tucson, Arizona, USA.
Todd W VanderahDepartment of Pharmacology, University of Arizona, Tucson, Arizona, USA.
University of Arizona · USNortheastern University · USIndiana University Bloomington · US

Funding

THERAPEUTIC PROFILES OF OPIOID DELTA RECEPTORS--NEW MODALITIESP01DA006284 · NIDA · UNIVERSITY OF ARIZONA · PI HRUBY, VICTOR J · 1989 to 2015
$14.8M
The Center of Excellence in Addiction Studies (CEAS)P30DA051355 · NIDA · UNIVERSITY OF ARIZONA · PI PORRECA, FRANK, VANDERAH, TODD W · 2021 to 2025
$6.7M
Cannabinoid CB2 Agonists for Treatment of Breast Cancer-Induced Bone PainR01CA142115 · NCI · UNIVERSITY OF ARIZONA · PI VANDERAH, TODD W · 2010 to 2021
$3.3M
Structured Illumination Fluorescence MicroscopeS10OD019948 · OD · UNIVERSITY OF ARIZONA · PI ELLIOTT, DAVID A · 2015 to 2015
$517k
Primary Afferent Transmission in the Trigeminal Dorsal HornF32DE022499 · NIDCR · OREGON HEALTH & SCIENCE UNIVERSITY · PI MILNES, TALLY MARIE · 2011 to 2014
$127k
NCI NIH HHS R01 CA142115NIDA NIH HHS P01 DA006284NIDA NIH HHS P30 DA051355NIDCR NIH HHS F32 DE022499NIH HHS S10 OD019948
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

CannabinoidsRespiratory InsufficiencyAnalgesics, OpioidAnimalsCannabinoid Receptor AgonistsMaleMiceMorphineAnalgesics, OpioidCannabinoid Receptor AgonistsCannabinoidsMorphinecannabinoid receptor 1cannabinoid receptor 2mu opioid receptoropioid-induced respiratory depressionpreBötzinger complex

Identifiers

PMID33998869
PMCPMC8612410
OpenAlexW3100672006

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.