Evidence map›Paper›PMID 33998809›Full record

ArticleACS applied materials & interfaces2021

Bioactive Functional Nanolayers of Chitosan-Lysine Surfactant with Single- and Mixed-Protein-Repellent and Antibiofilm Properties for Medical Implants.

Urban Ajdnik, Lidija Fras Zemljič, Olivija Plohl, Lourdes Pérez, Janja Trček, Matej Bračič, Tamilselvan Mohan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS applied materials & interfaces, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Urban AjdnikFaculty of Mechanical Engineering, Institute of Engineering Materials and Design, Laboratory for Characterization and Processing of Polymers, University of Maribor, Smetanova ulica 17, 2000 Maribor, Slovenia.
Lidija Fras ZemljičFaculty of Mechanical Engineering, Institute of Engineering Materials and Design, Laboratory for Characterization and Processing of Polymers, University of Maribor, Smetanova ulica 17, 2000 Maribor, Slovenia.
Olivija PlohlFaculty of Mechanical Engineering, Institute of Engineering Materials and Design, Laboratory for Characterization and Processing of Polymers, University of Maribor, Smetanova ulica 17, 2000 Maribor, Slovenia.ORCID https://orcid.org/0000-0003-0620-6141
Lourdes PérezDepartment of Surfactants and Nanobiotechnology, Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), Jordi Girona 18-26, 08034 Barcelona, Spain.ORCID https://orcid.org/0000-0002-3696-021X
Janja TrčekFaculty of Natural Sciences and Mathematics, Department of Biology, University of Maribor, Koroška cesta 160, 2000 Maribor, Slovenia.ORCID https://orcid.org/0000-0002-5605-2972
Matej BračičFaculty of Mechanical Engineering, Institute of Engineering Materials and Design, Laboratory for Characterization and Processing of Polymers, University of Maribor, Smetanova ulica 17, 2000 Maribor, Slovenia.
Tamilselvan MohanInstitute for Chemistry and Technology of Biobased Systems (IBioSys), Graz University of Technology, Stremayrgasse 9, 8010 Graz, Austria.ORCID https://orcid.org/0000-0002-8569-1642

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Medical implant-associated infections resulting from biofilm formation triggered by unspecific protein adsorption are the prevailing cause of implant failure. However, implant surfaces rendered with multifunctional bioactive nanocoatings offer a promising alternative to prevent the initial attachment of bacteria and effectively interrupt biofilm formation. The need to research and develop novel and stable bioactive nanocoatings for medical implants and a comprehensive understanding of their properties in contact with the complex biological environment are crucial. In this study, we developed an aqueous stable and crosslinker-free polyelectrolyte-surfactant complex (PESC) composed of a renewable cationic polysaccharide, chitosan, a lysine-based anionic surfactant (77KS), and an amphoteric antibiotic, amoxicillin, which is widely used to treat a number of infections caused by bacteria. We successfully introduced the PESC as bioactive functional nanolayers on the "model" and "real" polydimethylsiloxane (PDMS) surfaces under dynamic and ambient conditions. Besides their high stability and improved wettability, these uniformly deposited nanolayers (thickness: 44-61 nm) with mixed charges exhibited strong repulsion toward three model blood proteins (serum albumin, fibrinogen, and γ-globulin) and their competitive interactions in the mixture in real-time, as demonstrated using a quartz crystal microbalance with dissipation (QCM-D). The functional nanolayers with a maximum negative zeta potential (ζ: -19 to -30 mV at pH 7.4), water content (1628-1810 ng cm

Indexed as

Anti-Bacterial AgentsCoated Materials, BiocompatibleSurface-Active AgentsBiofilmsChitosanEscherichia coliHydrophobic and Hydrophilic InteractionsLysineNanomedicineNanostructuresProstheses and ImplantsProteinsSiliconStaphylococcus aureusSurface PropertiesAnti-Bacterial AgentsChitosanCoated Materials, BiocompatibleLysineProteinsSiliconSurface-Active Agentsadsorptionantimicrobialbioactive coatingschitosanlysineprotein-repellentQCM-Dsilicone implants

Identifiers

PMID33998809
PMCPMC8289181

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.