Evidence map›Paper›PMID 33998716›Full record

ArticleClinical transplantation2021

Comparative incidence and outcomes of COVID-19 in kidney or kidney-pancreas transplant recipients versus kidney or kidney-pancreas waitlisted patients: A single-center study.

Carlos A Q Santos, Yoona Rhee, Edward F Hollinger, Oyedolamu K Olaitan, Erik Schadde, Vasil Peev, Samuel N Saltzberg, Martin Hertl

Open access · bronzeAbstract read
In one paragraph

Article in Clinical transplantation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 2 pooled it
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 2 syntheses or guidelines pooled it, 7 citations in OpenAlex.

  1. Clinical outcome in solid organ transplant recipients affected by COVID-19 compared to general population: a systematic review and meta-analysis.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2022
    Pooled it
  2. Pooled it
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Carlos A Q SantosDivision of Infectious Diseases, Department of Internal Medicine, Rush University Medical Center, Chicago, IL, USA.ORCID 0000-0002-6224-0371
Yoona RheeDivision of Infectious Diseases, Department of Internal Medicine, Rush University Medical Center, Chicago, IL, USA.
Edward F HollingerDivision of Abdominal Transplantation, Department of Surgery, Rush University Medical Center, Chicago, IL, USA.
Oyedolamu K OlaitanDivision of Abdominal Transplantation, Department of Surgery, Rush University Medical Center, Chicago, IL, USA.
Erik SchaddeDivision of Abdominal Transplantation, Department of Surgery, Rush University Medical Center, Chicago, IL, USA.
Vasil PeevDivision of Nephrology, Department of Internal Medicine, Rush University Medical Center, Chicago, IL, USA.
Samuel N SaltzbergDivision of Nephrology, Department of Internal Medicine, Rush University Medical Center, Chicago, IL, USA.
Martin HertlDivision of Abdominal Transplantation, Department of Surgery, Rush University Medical Center, Chicago, IL, USA.
Rush University Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCOVID-19 epidemiologic studies comparing immunosuppressed and immunocompetent patients may provide insight into the impact of immunosuppressants on outcomes.

methodsIn this retrospective cohort study, we assembled kidney or kidney-pancreas transplant recipients who underwent transplant from January 1, 2010, to June 30, 2020, and kidney or kidney-pancreas waitlisted patients who were ever on the waitlist from January 1, 2019, to June 30, 2020. We identified laboratory-confirmed COVID-19 until January 31, 2021, and tracked its outcomes by leveraging informatics infrastructure developed for an outcomes research network.

resultsCOVID-19 was identified in 62 of 887 kidney or kidney-pancreas transplant recipients and 20 of 434 kidney or kidney-pancreas waitlisted patients (7.0% vs. 4.6%, p = .092). Of these patients with COVID-19, hospitalization occurred in 48 of 62 transplant recipients and 8 of 20 waitlisted patients (77% vs. 40%, p = .002); intensive care unit admission occurred in 18 of 62 transplant recipients and 2 of 20 waitlisted patients (29% vs. 10%, p = .085); and 7 transplant recipients were mechanically ventilated and died, whereas no waitlisted patients were mechanically ventilated or died (11% vs. 0%, p = .116).

conclusionsOur study provides single-center data and an informatics approach that can be used to inform the design of multicenter studies.

Indexed as

COVID-19Kidney TransplantationHumansIncidenceKidneyPancreasRetrospective StudiesSARS-CoV-2Transplant RecipientsCOVID-19epidemiologykidney transplantkidney waitlist

Identifiers

PMID33998716
PMCPMC8209946
OpenAlexW3163563570

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.